The effect of the gastrectomy on survival in patients with metastatic gastric cancer: a study of ASMO

Date
2016Author
Yazici, OzanOzdemir, Nuriye
Duran, Ayse Ocak
Menekse, Serkan
Ali, Mehmet
Sendur, Nahit
Karaca, Halit
Goksel, Gamze
Arpaci, Erkan
Hacibekiroglu, Ilhan
Bilgetekin, Irem
Kacan, Turgut
Ozkan, Metin
Aksoy, Sercan
Aksoy, Asude
Cokmert, Suna
Uysal, Mukremin
Elkiran, Emin Tamer
Cicin, Irfan
Buyukberber, Suleyman
Zengin, Nurullah
Metadata
Show full item recordAbstract
Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p <= 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.
Source
FUTURE ONCOLOGYVolume
12Issue
3Collections
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