Multicenter retrospective analysis regarding the clinical manifestations and treatment results in patients with hairy cell leukemia: twenty-four year Turkish experience in cladribine therapy
dc.contributor.author | Hacioglu, Sibel | |
dc.contributor.author | Bilen, Yusuf | |
dc.contributor.author | Eser, Ali | |
dc.contributor.author | Sivgin, Serdar | |
dc.contributor.author | Gurkan, Emel | |
dc.contributor.author | Yildirim, Rahsan | |
dc.contributor.author | Aydogdu, Ismet | |
dc.contributor.author | Dogu, Mehmet Hilmi | |
dc.contributor.author | Yilmaz, Mehmet | |
dc.contributor.author | Kayikci, Omur | |
dc.contributor.author | Tombak, Anil | |
dc.contributor.author | Kuku, Irfan | |
dc.contributor.author | Celebi, Harika | |
dc.contributor.author | Akay, Meltem Olga | |
dc.contributor.author | Esen, Ramazan | |
dc.contributor.author | Korkmaz, Serdal | |
dc.contributor.author | Keskin, Ali | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:14Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:14Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0278-0232 | |
dc.identifier.issn | 1099-1069 | |
dc.identifier.uri | https://dx.doi.org/10.1002/hon.2177 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7645 | |
dc.description | WOS: 000368248400011 | en_US |
dc.description | PubMed ID: 25393847 | en_US |
dc.description.abstract | In this multicenter retrospective analysis, we aimed to present clinical, laboratory and treatment results of 94 patients with Hairy cell leukemia diagnosed in 13 centers between 1990 and 2014. Sixty-six of the patients were males and 28 were females, with a median age of 55. Splenomegaly was present in 93.5% of cases at diagnosis. The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis. Most of the patients with an indication for treatment were treated with cladribine as first-line treatment. Total and complete response of cladribine was 97.3% and 80.7%. The relapse rate after cladribine was 16.6%, and treatment related mortality was 2.5%. Most preferred therapy ( 95%) was again cladribine at second-line, and third line with CR rate of 68.4% and 66.6%, respectively. The 28-month median OS was 91.7% in all patients and 25-month median OS 96% for patients who were given cladribine as first-line therapy. In conclusion, the first multicenter retrospective Turkish study where patients with HCL were followed up for a long period has revealed demographic characteristics of patients with HCL, and confirmed that cladribine treatment might be safe and effective in a relatively large series of the Turkish study population. Copyright (C) 2014 John Wiley & Sons, Ltd. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1002/hon.2177 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | hairy cell leukemia | en_US |
dc.subject | Turkey | en_US |
dc.subject | treatment | en_US |
dc.subject | cladribin | en_US |
dc.subject | survival | en_US |
dc.title | Multicenter retrospective analysis regarding the clinical manifestations and treatment results in patients with hairy cell leukemia: twenty-four year Turkish experience in cladribine therapy | en_US |
dc.type | article | en_US |
dc.relation.journal | HEMATOLOGICAL ONCOLOGY | en_US |
dc.contributor.department | [Hacioglu, Sibel -- Dogu, Mehmet Hilmi -- Keskin, Ali] Pamukkale Univ, Dept Hematol, TR-20070 Denizli, Turkey -- [Bilen, Yusuf -- Yildirim, Rahsan] Ataturk Univ, Dept Hematol, Erzurum, Turkey -- [Eser, Ali] Marmara Univ, Dept Hematol, Istanbul, Turkey -- [Sivgin, Serdar] Erciyes Univ, Dept Hematol, Kayseri, Turkey -- [Gurkan, Emel] Cukurova Univ, Dept Hematol, Adana, Turkey -- [Aydogdu, Ismet] Celal Bayar Univ, Dept Hematol, Manisa, Turkey -- [Yilmaz, Mehmet] Gaziantep Univ, Dept Hematol, Gaziantep, Turkey -- [Kayikci, Omur] Ankara Oncol Educ & Res Hosp, Dept Hematol, Ankara, Turkey -- [Tombak, Anil] Mersin Univ, Dept Hematol, Mersin, Turkey -- [Kuku, Irfan] Inonu Univ, Dept Hematol, Malatya, Turkey -- [Celebi, Harika] Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Hematol, Ankara, Turkey -- [Akay, Meltem Olga] Osmangazi Univ, Dept Hematol, Eskisehir, Turkey -- [Esen, Ramazan] Yuzuncu Yil Univ, Dept Hematol, Van, Turkey -- [Korkmaz, Serdal] Cumhuriyet Univ, Dept Hematol, Sivas, Turkey | en_US |
dc.contributor.authorID | GURKAN, EMEL -- 0000-0002-3060-4054 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 198 | en_US |
dc.identifier.startpage | 192 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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