dc.contributor.author | Duksal, Fatma | |
dc.contributor.author | Kurtulgan, Hande Kucuk | |
dc.contributor.author | Cevit, Omer | |
dc.contributor.author | Koksah, Binnur | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:20Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:20Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1309-0720 | |
dc.identifier.issn | 1309-2014 | |
dc.identifier.uri | https://dx.doi.org/10.4328/JCAM.3536 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7662 | |
dc.description | WOS: 000215600200008 | en_US |
dc.description.abstract | Aim: It was aimed to show the relationship between childhood asthma and C3435T multidrug resistance 1 gene polymorphism. Material and Method: Fifty eight children with asthma and 54 healthy children participated to the study. Chi-square and Fisher exact tests were used for statistical analysis. Results: Wild, heterozygous and homozygous polymorphism for multidrug resistance - 1 gene were found respectively in 12 (20.7%), 31 (53.4%), and 15 (25.9%) of children with asthma. In healthy children, wild, heterozygous, and homozygous polymorphisms were found respectively in 18 (33.3%), 28 (51.9%), and 8 (14.8%) participants. There was no statistical difference between asthmatic and healthy children in terms of multidrug resistance 1 gene polymorphism. Homozygous polymorphism was found higher in severe persistent group than moderate and mild persistent groups (p=0.001) and in girls than boys (p=0.001). Discussion: It may be said that the difference was resulted from severe persistent asthmatic patients. And this information helps clinicians to rank the patients in terms of asthma by looking multidrug resistance 1 gene when the patient was diagnosed as asthma. Hence, treatment of patients, especially with crucial degree may begin earlier and its long-term pursuance can be made. In addition, gender-specific treatment can be planned especially for female patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | DERMAN MEDICAL PUBL | en_US |
dc.relation.isversionof | 10.4328/JCAM.3536 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Asthma | en_US |
dc.subject | Children | en_US |
dc.subject | Multidrug Resistance-1 Gene | en_US |
dc.title | Relationship Between Childhood Asthma and C3435T Multidrug Resistance 1 Gene | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE | en_US |
dc.contributor.department | [Duksal, Fatma -- Cevit, Omer] Cumhuriyet Univ, Tip Fak, Pediat ABD, Sivas, Turkey -- [Kurtulgan, Hande Kucuk -- Koksah, Binnur] Cumhuriyet Univ, Tip Fak, Genet ABD, Sivas, Turkey | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.endpage | 760 | en_US |
dc.identifier.startpage | 756 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |