dc.contributor.author | Hayta, Emrullah | |
dc.contributor.author | Hizmetli, Sami | |
dc.contributor.author | Atalar, Mehmet Haydar | |
dc.contributor.author | Cinar, Ziynet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:49Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2148-5046 | |
dc.identifier.issn | 1309-0283 | |
dc.identifier.uri | https://dx.doi.org/10.5606/ArchRheumatol.2015.4249 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7728 | |
dc.description | WOS: 000363083300005 | en_US |
dc.description.abstract | Objectives: This study aims to evaluate the relationship between serum homocysteine levels and atherosclerotic plaques in carotid arteries in female patients with rheumatoid arthritis (RA). Patients and methods: Fifty-eight females with RA (mean age 45.50 +/- 11.69 years; range 42 to 60 years) and 22 female controls (mean age 47.3 +/- 8.9 years; range 38 to 62 years) with mechanical low back pain were included in the study. RA patients were divided into two groups: patients who were under methotrexate (MTX) therapy at least for two years (MTX group, n=32), and patients who did not receive MTX at least for past two years (non-MTX-disease-modifying antirheumatic drug group, n=26). RA patients' disease activity scores in 28 joints were calculated. Carotid intima-media thickness and presence of atherosclerotic plaque were evaluated by high-resolution B-mode ultrasonography. Results: Plasma homocysteine levels were higher in MTX and non-MTX-disease-modifying antirheumatic drug groups compared to controls (16.88 +/- 6.84 and 10.37 +/- 2.54 mu mol/L, respectively) and the difference was statistically significant (p=0.001). In MTX, non-MTX-disease-modifying antirheumatic drug and control groups, atherosclerotic plaque was detected in 11 (34.5%) and four (15.4%) patients, and one patient (4.5%), respectively. Carotid intima-media thickness was significantly higher in MTX group compared to other two groups and the difference was statistically significant (p=0.002). Pearson correlation analysis revealed a significant correlation between intima-media thickness and homocysteine levels in MTX group (r=0.49, p=0.006). Conclusion: According to our study results, methotrexate treatment in female patients with RA increases plasma homocysteine levels and prevalence of atherosclerotic plaque. High homocysteine levels in these patients may be a cause of atherosclerosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TURKISH LEAGUE AGAINST RHEUMATISM | en_US |
dc.relation.isversionof | 10.5606/ArchRheumatol.2015.4249 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | B-mode ultrasonography | en_US |
dc.subject | homocysteine | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.title | Association of Plasma Homocysteine Level and Carotid Intima-Media Thickness in Rheumatoid Arthritis Patients Receiving Methotrexate | en_US |
dc.type | article | en_US |
dc.relation.journal | ARCHIVES OF RHEUMATOLOGY | en_US |
dc.contributor.department | [Hayta, Emrullah -- Hizmetli, Sami] Cumhuriyet Univ, Tip Fak, Fiziksel Tip & Rehabilitasyon Anabilim Dali, TR-58140 Sivas, Turkey -- [Atalar, Mehmet Haydar] Cumhuriyet Univ, Dept Radiol, Fac Med, TR-58140 Sivas, Turkey -- [Cinar, Ziynet] Cumhuriyet Univ, Dept Biostat, Fac Med, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 220 | en_US |
dc.identifier.startpage | 214 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |