dc.contributor.author | Arslan, Serdal | |
dc.contributor.author | Korkmaz, Ozge | |
dc.contributor.author | Ozbilum, Nil | |
dc.contributor.author | Berkan, Ocal | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:51Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:51Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2049-9434 | |
dc.identifier.issn | 2049-9442 | |
dc.identifier.uri | https://dx.doi.org/10.3892/br.2015.499 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7731 | |
dc.description | WOS: 000362836300024 | en_US |
dc.description.abstract | Coronary artery disease (CAD) is the leading cause of fatalities worldwide. Nuclear factor (NF)-kappa B is a transcription factor that controls cell proliferation, differentiation and immunity. To the best of our knowledge, the present study is the first investigation of the association between CAD and NF-kappa B1 -94 W/D/NF-kappa BIA 3'-untranslated region (3'-UTR) A -> G polymorphisms. The study population comprised 226 CAD patients and 201 controls. There was no significant difference in NF-kappa B1A 3'-UTR A -> G in the allele and genotype frequencies between case and control populations. The D allele frequency of NF-kappa B1 -94 in the case group was significantly higher compared to the control group (P= 0.028, odds ratio= 1.37). The genotype frequency of NF-kappa B1 -94 DD in the case group was significantly higher compared to the controls (P= 0.028). Linkage analysis showed a close linkage among these 2 genes (P< 0.001 for case and control), and AD and GD haplotypes were associated with CAD (P< 0.001; P= 0.015, respectively). NF-kappa B1 -94 DD genotype can be a significant risk factor for the development of CAD. | en_US |
dc.description.sponsorship | Research Council of Cumhuriyet University (CUBAP), Sivas, Turkey [F-340] | en_US |
dc.description.sponsorship | The present study was supported by the Research Council of Cumhuriyet University (CUBAP, project no. F-340), Sivas, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.relation.isversionof | 10.3892/br.2015.499 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | coronary artery disease | en_US |
dc.subject | genetic polymorphism | en_US |
dc.subject | nuclear factor-kappa BIA | en_US |
dc.subject | nuclear factor-kappa B1 | en_US |
dc.title | Association between NF-kappa BI and NF-kappa BIA polymorphisms and coronary artery disease | en_US |
dc.type | article | en_US |
dc.relation.journal | BIOMEDICAL REPORTS | en_US |
dc.contributor.department | [Arslan, Serdal] Cumhuriyet Univ, Dept Med Biol, TR-58140 Sivas, Turkey -- [Korkmaz, Ozge -- Berkan, Ocal] Cumhuriyet Univ, Fac Med, Dept Cardiovasc Surg, TR-58140 Sivas, Turkey -- [Ozbilum, Nil] Cumhuriyet Univ, Fac Sci, Dept Mol Biol & Genet, 3 Kayseri St, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 740 | en_US |
dc.identifier.startpage | 736 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |