dc.contributor.author | Gueven, A. S. | |
dc.contributor.author | Icagasioglu, F. D. | |
dc.contributor.author | Duksal, F. | |
dc.contributor.author | Sancakdar, E. | |
dc.contributor.author | Alaygut, D. | |
dc.contributor.author | Uysal, E. B. | |
dc.contributor.author | Akkar, I. | |
dc.contributor.author | Oflaz, M. B. | |
dc.contributor.author | Kaya, A. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:57Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:57Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0960-3271 | |
dc.identifier.issn | 1477-0903 | |
dc.identifier.uri | https://dx.doi.org/10.1177/0960327114561662 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7746 | |
dc.description | WOS: 000360090300003 | en_US |
dc.description | PubMed ID: 25504688 | en_US |
dc.description.abstract | Proinflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of febrile seizures (FS). Adipocytokines like interleukin 6 (IL-6), leptin, and adiponectin released from adipose tissue play a role in inflammation. This study aimed to assess the probable role of adipose tissue in children with FS. We measured serum IL-6, leptin, and adiponectin levels and evaluated clinical and laboratory findings in children with FS (n = 32) and compared the results with the values of children of the same age with febrile illness without seizures (febrile control, FC; n = 26) and healthy control group (HC; n = 29). The serum levels of white blood cells, C-reactive protein, IL-6, leptin, and adiponectin were found to be significantly higher, while serum hemoglobin (Hb) levels were found to be significantly lower in FS and FC groups than in the HC group (p < 0.001). When we compared the FS with the FC group, the serum Hb levels were significantly lower in the FS group than those in the FC group (p = 0.001). There was no significant difference between the FS and FC group with regard to the serum levels of these adipocytokines (p > 0.05). Our data showed that elevated levels of these adipocytokines as acute phase reactants in FS and FC groups did not contribute to the development of FS. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SAGE PUBLICATIONS LTD | en_US |
dc.relation.isversionof | 10.1177/0960327114561662 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Adipocytokines | en_US |
dc.subject | adiponectin | en_US |
dc.subject | leptin | en_US |
dc.subject | IL-6 | en_US |
dc.subject | febrile seizures | en_US |
dc.title | Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures: The role of adipose tissue in febrile seizures | en_US |
dc.type | article | en_US |
dc.relation.journal | HUMAN & EXPERIMENTAL TOXICOLOGY | en_US |
dc.contributor.department | [Gueven, A. S. -- Icagasioglu, F. D.] Cumhuriyet Univ, Dept Pediat, Div Pediat Neurol, Fac Med, TR-58140 Sivas, Turkey -- [Duksal, F. -- Alaygut, D. -- Oflaz, M. B. -- Kaya, A.] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Sancakdar, E.] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Uysal, E. B.] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Akkar, I.] Sivas Govt Hosp, Dept Pediat, Sivas, Turkey | en_US |
dc.contributor.authorID | Oflaz, Mehmet Burhan -- 0000-0003-1515-4654 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.endpage | 883 | en_US |
dc.identifier.startpage | 878 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |