Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma
dc.contributor.author | Turan, Nedim | |
dc.contributor.author | Benekli, Mustafa | |
dc.contributor.author | Unal, Olcun Umit | |
dc.contributor.author | Unek, Ilkay Tugba | |
dc.contributor.author | Tastekin, Didem | |
dc.contributor.author | Dane, Faysal | |
dc.contributor.author | Algin, Efnan | |
dc.contributor.author | Ulger, Sukran | |
dc.contributor.author | Eren, Tulay | |
dc.contributor.author | Topcu, Turkan Ozturk | |
dc.contributor.author | Turkmen, Esma | |
dc.contributor.author | Babacan, Nalan Akgul | |
dc.contributor.author | Tufan, Gulnihal | |
dc.contributor.author | Urakci, Zuhat | |
dc.contributor.author | Ustaalioglu, Basak Oven | |
dc.contributor.author | Uysal, Ozlem Sonmez | |
dc.contributor.author | Ercelep, Ozlem Balvan | |
dc.contributor.author | Taskoylu, Burcu Yapar | |
dc.contributor.author | Aksoy, Asude | |
dc.contributor.author | Canhoroz, Mustafa | |
dc.contributor.author | Demirci, Umut | |
dc.contributor.author | Dogan, Erkan | |
dc.contributor.author | Berk, Veli | |
dc.contributor.author | Balakan, Ozan | |
dc.contributor.author | Ekinci, Ahmet Siyar | |
dc.contributor.author | Uysal, Mukremin | |
dc.contributor.author | Petekkaya, Ibrahim | |
dc.contributor.author | Ozturk, Selcuk Cemil | |
dc.contributor.author | Tonyali, Onder | |
dc.contributor.author | Cetin, Bulent | |
dc.contributor.author | Aldemir, Mehmet Naci | |
dc.contributor.author | Helvaci, Kaan | |
dc.contributor.author | Ozdemir, Nuriye | |
dc.contributor.author | Oztop, Ilhan | |
dc.contributor.author | Coskun, Ugur | |
dc.contributor.author | Uner, Aytug | |
dc.contributor.author | Ozet, Ahmet | |
dc.contributor.author | Buyukberber, Suleyman | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:48:09Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:48:09Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1000-9604 | |
dc.identifier.issn | 1993-0631 | |
dc.identifier.uri | https://dx.doi.org/10.3978/j.issn.1000-9604.2015.08.03 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7771 | |
dc.description | WOS: 000360940900010 | en_US |
dc.description | PubMed ID: 26361410 | en_US |
dc.description.abstract | Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AME PUBL CO | en_US |
dc.relation.isversionof | 10.3978/j.issn.1000-9604.2015.08.03 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pancreatic adenocarcinoma | en_US |
dc.subject | adjuvant chemotherapy (adjuvant CT) | en_US |
dc.subject | adjuvant radiotherapy | en_US |
dc.title | Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma | en_US |
dc.type | article | en_US |
dc.relation.journal | CHINESE JOURNAL OF CANCER RESEARCH | en_US |
dc.contributor.department | [Turan, Nedim -- Babacan, Nalan Akgul] Cumhuriyet Univ, Fac Med, Dept Med Oncol, TR-58140 Sivas, Turkey -- [Benekli, Mustafa -- Algin, Efnan -- Cetin, Bulent -- Coskun, Ugur -- Uner, Aytug -- Ozet, Ahmet -- Buyukberber, Suleyman] Gazi Univ, Fac Med, Dept Med Oncol, TR-06560 Ankara, Turkey -- [Unal, Olcun Umit -- Unek, Ilkay Tugba -- Oztop, Ilhan] Dokuz Eylul Univ, Fac Med, Dept Med Oncol, TR-35340 Izmir, Turkey -- [Tastekin, Didem] Necmettin Erbakan Univ, Fac Med, Dept Med Oncol, TR-42080 Konya, Turkey -- [Dane, Faysal] Marmara Univ, Fac Med, Dept Med Oncol, TR-34000 Istanbul, Turkey -- [Ulger, Sukran] Gazi Univ, Fac Med, Dept Radiat Oncol, TR-06560 Ankara, Turkey -- [Eren, Tulay -- Ozdemir, Nuriye] Numune Educ & Res Hosp, Dept Med Oncol, TR-06100 Ankara, Turkey -- [Topcu, Turkan Ozturk] Karadeniz Tech Univ, Fac Med, Dept Med Oncol, TR-61000 Trabzon, Turkey -- [Turkmen, Esma] Trakya Univ, Fac Med, Dept Med Oncol, TR-22020 Edirne, Turkey -- [Tufan, Gulnihal] Rize Educ & Res Hosp, Dept Med Oncol, TR-53200 Rize, Turkey -- [Urakci, Zuhat] Dicle Univ, Fac Med, Dept Med Oncol, TR-21280 Diyarbakir, Turkey -- [Ustaalioglu, Basak Oven -- Ercelep, Ozlem Balvan] Dr Lutfi Kirdar Kartal Educ & Res Hosp, Dept Med Oncol, TR-34668 Istanbul, Turkey -- [Uysal, Ozlem Sonmez] Sakarya Educ & Res Hosp, Dept Med Oncol, TR-54050 Sakarya, Turkey -- [Taskoylu, Burcu Yapar] Pamukkale Univ, Fac Med, Dept Med Oncol, TR-20070 Denizli, Turkey -- [Aksoy, Asude] Inonu Univ, Fac Med, Dept Med Oncol, TR-44315 Malatya, Turkey -- [Canhoroz, Mustafa] Firat Univ, Fac Med, Dept Med Oncol, TR-23200 Elazig, Turkey -- [Demirci, Umut -- Helvaci, Kaan] Dr Abdurrahman Yurtaslan Educ & Res Hosp, Dept Med Oncol, TR-06200 Ankara, Turkey -- [Dogan, Erkan] Yuzuncu Yil Univ, Fac Med, Dept Med Oncol, TR-65080 Van, Turkey -- [Berk, Veli] Erciyes Univ, Fac Med, Dept Med Oncol, TR-38000 Kayseri, Turkey -- [Balakan, Ozan] SutcuImam Univ, Fac Med, Dept Med Oncol, TR-46100 Kahramanmaras, Turkey -- [Ekinci, Ahmet Siyar] Diyarbakir Educ & Res Hosp, Dept Med Oncol, TR-21010 Diyarbakir, Turkey -- [Uysal, Mukremin] Afyon Kocatepe Univ, Fac Med, Dept Med Oncol, TR-03200 Afyon, Turkey -- [Petekkaya, Ibrahim] Dr Ersin Arslan State Hosp, Dept Med Oncol, TR-27010 Gaziantep, Turkey -- [Ozturk, Selcuk Cemil] Adiyaman Univ, Educ & Res Hosp, Dept Med Oncol, TR-02040 Adiyaman, Turkey -- [Tonyali, Onder] Mustafa Kemal Univ, Fac Med, Dept Med Oncol, TR-31070 Antakya, Turkey -- [Aldemir, Mehmet Naci] Ataturk Univ, Fac Med, Dept Med Oncol, TR-25240 Erzurum, Turkey | en_US |
dc.contributor.authorID | DEMIRCI, UMUT -- 0000-0002-4833-6721; aksoy, asude -- 0000-0002-5609-9658; benekli, mustafa -- 0000-0003-3184-4946 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 416 | en_US |
dc.identifier.startpage | 408 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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