dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Guven, Ahmet S. | |
dc.contributor.author | Uysal, Elif B. | |
dc.contributor.author | Deveci, Koksal | |
dc.contributor.author | Gulturk, Esra | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:48:14Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:48:14Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0891-3668 | |
dc.identifier.issn | 1532-0987 | |
dc.identifier.uri | https://dx.doi.org/10.1097/INF.0000000000000706 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7780 | |
dc.description | WOS: 000358411800003 | en_US |
dc.description | PubMed ID: 25831422 | en_US |
dc.description.abstract | Background: Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection. Methods: Thirty one CCHF patients and 31 healthy controls (HC) were included in the study. CCHF patients were classified into 2 groups in terms of disease severity (severe and nonsevere). VEGF-A, VEGFR1, Ang-2 and Tie-2 levels were measured in all groups. Result: Serum levels of Tie-2, Ang-2, VEGF-A and VEGFR1 were significantly increased in CCHF patients compared with the HC. Furthermore, serum Tie-2, Ang-2, VEGF and VEGFR1 levels were found to be significantly higher in the severe group than in the nonsevere and HC groups (P < 0.05 and P < 0.001, respectively). Also, Tie-2, Ang-2, VEGF-A and VEGFR1 levels were significantly higher in the nonsevere group than in the HC group (P < 0.05). Conclusion: Having statistically significant higher Ang-2, Tie-2, VEGF-A and VEGFR1 levels in the severe group when compared with the other groups suggested that VEGF-related Ang-2/Tie-2 system played a critical role in the pathogenesis of the disease, and these markers could be used as the severity criteria. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.isversionof | 10.1097/INF.0000000000000706 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Crimean-Congo hemorrhagic fever | en_US |
dc.subject | angiogenesis | en_US |
dc.subject | angiopoietin-2 | en_US |
dc.subject | Tie-2 | en_US |
dc.subject | VEGF | en_US |
dc.title | Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean-Congo Hemorrhagic Fever | en_US |
dc.type | article | en_US |
dc.relation.journal | PEDIATRIC INFECTIOUS DISEASE JOURNAL | en_US |
dc.contributor.department | [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Guven, Ahmet S.] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Uysal, Elif B.] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Gulturk, Esra] Cumhuriyet Univ, Fac Med, Dept Biostat, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.endpage | E205 | en_US |
dc.identifier.startpage | E200 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |