dc.description.abstract | Introduction. It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) influences the aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. We aimed to investigate whether there is an effect of CYP11B2 -344C>T polymorphism on the development of CKD in a Turkish population. Material and Methods. A total of 240 patients with stage 5 CKD and 240 age- and sex-matched healthy individuals were included in the study. Genotyping of CYP11B2 gene -344 T>C promoter polymorphism was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. Results. No significant differences were found in the genotype distribution of CYP11B2 -344 C>T polymorphism between the patients and controls; however, -344 C>T polymorphism was significantly more frequent among the CKD patients with diabetes mellitus as compared to those with it (P = .02). Diabetic CKD patients with TC genotype had a 2-fold increased risk for development of the disease than the CKD patients without diabetes mellitus (odds ratio, 2.21; 95% confidence interval, 1.04 to 4.67). Conclusions. Our study suggests that the CYP11B2 gene -344 C>T polymorphism may have an effect on the development of CKD in diabetic patients. | en_US |
dc.contributor.department | [Yilmaz, Meral] Cumhuriyet Univ, Sch Med, Dept Res Ctr, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth, Dept Nutr & Diet, Sivas, Turkey -- [Gumus, Erkan] Cumhuriyet Univ, Sch Med, Dept Histol & Embryol, Sivas, Turkey -- [Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Sch Med, Dept Med Genet, Canakkale, Turkey | en_US |