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dc.contributor.authorYalcintepe, Sinem
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorHacivelioglu, Servet Ozden
dc.contributor.authorAkurut, Cisem
dc.contributor.authorKoc, Evrim
dc.contributor.authorUludag, Ahmet
dc.contributor.authorCosar, Emine
dc.contributor.authorSilan, Fatma
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:56:16Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:56:16Z
dc.date.issued2015
dc.identifier.issn2251-9637
dc.identifier.issn2251-9645
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7923
dc.descriptionWOS: 000363549000006en_US
dc.descriptionPubMed ID: 26261801en_US
dc.description.abstractThe aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genotyped and correlated in spontaneously aborted fetal materials, their mothers and fertile women. Twenty three abortion materials, 22 women with >= 1 unexplained fetal loss, and 22 control subjects with at least two healthy term infants as a control group were studied. Target SNPs for each gene were analyzed by real time-PCR technique after genomic DNA isolation from maternal blood-EDTA, control group blood-EDTA and spontaneously aborted fetal tissues. Some cases had a single thrombophilic polymorphism, but the rest of the patients and fetal materials had combined thrombophilic polymorphisms. The PAI-1 4G/5G+4G/4G (P=0.0017), 4G/4G (P=0.0253), eNOS 894GT+894TT (P=0.0011) genotypes and T allele (P=0.0185), Apo E E3/E4+E3/E2+E2/E4 (P<0.0001) genotypes, E2 (P<0.0001) and E4 (P<0.0001) alleles were higher in spontaneously aborted fetal materials when compared to their mothers and control group. The Factor V Leiden rs6025, Prothrombin G20210A, MTHFR C677T, ACE I/D genotypes were different for each group but not statistically significant due to relatively small size of the samples (P>0.05). Our results indicated that combined thrombophilic gene variations may be associated with increased risk for spontaneous abortions and results need to be confirmed by larger sample size.en_US
dc.description.sponsorshipScientific Research Projects fund of Canakkale Onsekiz Mart University (COMU-BAP) [2012-029]; ethics committee of COMUen_US
dc.description.sponsorshipThis project was funded by Scientific Research Projects fund of Canakkale Onsekiz Mart University (COMU-BAP, 2012-029) and supported by the ethics committee of COMU.en_US
dc.language.isoengen_US
dc.publisherCELLULAR & MOLECULAR BIOLOGY RESEARCH CENTERen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpontaneous abortionen_US
dc.subjectthrombophiliaen_US
dc.subjectpolymorphismen_US
dc.subjectfetusen_US
dc.titleMultiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Populationen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINEen_US
dc.contributor.department[Yalcintepe, Sinem -- Ozdemir, Ozturk -- Akurut, Cisem -- Uludag, Ahmet -- Silan, Fatma] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Genet, Canakkale, Turkey -- [Yalcintepe, Sinem] Numune Training & Educ Hosp, Genet Diag Ctr, Adana, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey -- [Hacivelioglu, Servet Ozden -- Koc, Evrim -- Cosar, Emine] Canakkale Onsekiz Mart Univ, Sch Med, Dept Gynecol & Obstet, Canakkale, Turkeyen_US
dc.identifier.volume4en_US
dc.identifier.issue2en_US
dc.identifier.endpage127en_US
dc.identifier.startpage120en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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