dc.contributor.author | Yalcintepe, Sinem | |
dc.contributor.author | Ozdemir, Ozturk | |
dc.contributor.author | Hacivelioglu, Servet Ozden | |
dc.contributor.author | Akurut, Cisem | |
dc.contributor.author | Koc, Evrim | |
dc.contributor.author | Uludag, Ahmet | |
dc.contributor.author | Cosar, Emine | |
dc.contributor.author | Silan, Fatma | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:16Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:16Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2251-9637 | |
dc.identifier.issn | 2251-9645 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7923 | |
dc.description | WOS: 000363549000006 | en_US |
dc.description | PubMed ID: 26261801 | en_US |
dc.description.abstract | The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genotyped and correlated in spontaneously aborted fetal materials, their mothers and fertile women. Twenty three abortion materials, 22 women with >= 1 unexplained fetal loss, and 22 control subjects with at least two healthy term infants as a control group were studied. Target SNPs for each gene were analyzed by real time-PCR technique after genomic DNA isolation from maternal blood-EDTA, control group blood-EDTA and spontaneously aborted fetal tissues. Some cases had a single thrombophilic polymorphism, but the rest of the patients and fetal materials had combined thrombophilic polymorphisms. The PAI-1 4G/5G+4G/4G (P=0.0017), 4G/4G (P=0.0253), eNOS 894GT+894TT (P=0.0011) genotypes and T allele (P=0.0185), Apo E E3/E4+E3/E2+E2/E4 (P<0.0001) genotypes, E2 (P<0.0001) and E4 (P<0.0001) alleles were higher in spontaneously aborted fetal materials when compared to their mothers and control group. The Factor V Leiden rs6025, Prothrombin G20210A, MTHFR C677T, ACE I/D genotypes were different for each group but not statistically significant due to relatively small size of the samples (P>0.05). Our results indicated that combined thrombophilic gene variations may be associated with increased risk for spontaneous abortions and results need to be confirmed by larger sample size. | en_US |
dc.description.sponsorship | Scientific Research Projects fund of Canakkale Onsekiz Mart University (COMU-BAP) [2012-029]; ethics committee of COMU | en_US |
dc.description.sponsorship | This project was funded by Scientific Research Projects fund of Canakkale Onsekiz Mart University (COMU-BAP, 2012-029) and supported by the ethics committee of COMU. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | CELLULAR & MOLECULAR BIOLOGY RESEARCH CENTER | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Spontaneous abortion | en_US |
dc.subject | thrombophilia | en_US |
dc.subject | polymorphism | en_US |
dc.subject | fetus | en_US |
dc.title | Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE | en_US |
dc.contributor.department | [Yalcintepe, Sinem -- Ozdemir, Ozturk -- Akurut, Cisem -- Uludag, Ahmet -- Silan, Fatma] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Genet, Canakkale, Turkey -- [Yalcintepe, Sinem] Numune Training & Educ Hosp, Genet Diag Ctr, Adana, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey -- [Hacivelioglu, Servet Ozden -- Koc, Evrim -- Cosar, Emine] Canakkale Onsekiz Mart Univ, Sch Med, Dept Gynecol & Obstet, Canakkale, Turkey | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 127 | en_US |
dc.identifier.startpage | 120 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |