dc.contributor.author | Yilmaz, Meral | |
dc.contributor.author | Elaldi, Nazif | |
dc.contributor.author | Bagci, Binnur | |
dc.contributor.author | Sari, Ismail | |
dc.contributor.author | Gumus, Erkan | |
dc.contributor.author | Yelkovan, Izzet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:16Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:16Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0972-9062 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7929 | |
dc.description | WOS: 000355242400004 | en_US |
dc.description | PubMed ID: 25815864 | en_US |
dc.description.abstract | Objective: In this case-control study, we investigated whether IL-6 (-174G/C) and TNF-alpha (-308G/A) gene polymorphisms affect the clinical course and outcome of CCHF. Methods: Total 150 patients with CCHF and 170 controls were examined in this study. Genotyping of these polymorphisms were performed by PCR-RFLP methods. Results: We found no statistically significant differences in genotype and allele frequencies of these polymorphisms between patients and controls [(chi(2) = 1.31, p = 0.51 for TNF-alpha) and (chi(2)=2.61, p = 0.27 for IL-6)]. Either TNF-alpha AA or IL-6 CC genotypes in dead cases were not observed in this study. Frequency of heterozygous genotypes in both IL-6 (GC) and TNF-alpha (GA) was higher in dead patients than living patients. However, the difference was not statistically significant. A significant difference was found in AST levels and INR when compared to patients with CCHF who died and who survived [OR = 13.9 (95% CI = 1.79-107) for INR, p = 0.01] and [OR = 23.3 (95% CI = 3.62-149) for AST, p = 0.001], respectively. Conclusion: We did not find a significant association of IL-6 -174G/C and TNF-alpha -308G/A polymorphisms on the prognosis of CCHF and mortality in this study. We suggest that AST and INR may be important biomarkers for determining the risk of severity and death as a result of infection with Crimean-Congo hemorrhagic fever virus (CCHFV). | en_US |
dc.description.sponsorship | Cumhuriyet University Research Committee [T-429] | en_US |
dc.description.sponsorship | This work was supported by a grant from Cumhuriyet University Research Committee (Project No: T-429) and individual facilities and funds. We used some laboratory facilities in the Research Centre, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Crimean-Congo hemorrhagic fever (CCHF) | en_US |
dc.subject | IL-6 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | TNF-alpha | en_US |
dc.title | Effect of tumour necrosis factor-alpha and interleukin-6 promoter polymorphisms on course of Crimean-Congo hemorrhagic fever in Turkish patients | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF VECTOR BORNE DISEASES | en_US |
dc.contributor.department | [Yilmaz, Meral] Cumhuriyet Univ, Fac Med, Dept Res Ctr, Sivas, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Fac Med, Dept Nutr & Diet, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Fac Med, Dept Biochem Med, Sivas, Turkey -- [Gumus, Erkan] Cumhuriyet Univ, Fac Med, Dept Histol & Embryol, Sivas, Turkey -- [Yelkovan, Izzet] Cumhuriyet Univ, Fac Med, Dept Med Biol, Sivas, Turkey | en_US |
dc.contributor.authorID | SARI, Ismail -- 0000-0001-7737-4180; Elaldi, Nazif -- 0000-0002-9515-770X; Sari, Ismail -- 0000-0003-3732-2102 | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 35 | en_US |
dc.identifier.startpage | 30 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |