dc.contributor.author | Guven, Ahmet S. | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Uysal, Elif B. | |
dc.contributor.author | Kaya, Ali | |
dc.contributor.author | Oflaz, Mehmet B. | |
dc.contributor.author | Karapinar, Hekim | |
dc.contributor.author | Bolat, Fatih | |
dc.contributor.author | Tuzcu, Nevin | |
dc.contributor.author | Deveci, Koksal | |
dc.contributor.author | Cevit, Omer | |
dc.contributor.author | Icagasioglu, Fusun D. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:20Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:20Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0891-3668 | |
dc.identifier.issn | 1532-0987 | |
dc.identifier.uri | https://dx.doi.org/10.1097/INF.0000000000000530 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7956 | |
dc.description | WOS: 000349908800020 | en_US |
dc.description | PubMed ID: 25170551 | en_US |
dc.description.abstract | Background: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the levels of these apoptotic markers and the relation of these changes with disease severity. Methods: Forty-nine hospitalized children with CCHF and 36 healthy controls were enrolled in this prospective study. The CCHF patients were classified into 2 groups based on disease severity (severe group and nonsevere group). Demographic characteristics and clinical and laboratory findings of all patients were recorded on admission. Results: Serum perforin, caspase-3 and soluble Fas ligand levels were found to be significantly higher both in the severe and nonsevere CCHF groups than the healthy control group (P < 0.05), but there was no significant difference in these apoptotic markers between severe and nonsevere CCHF groups (P > 0.05). In addition, serum M-30 levels did not differ significantly among all groups (P > 0.05). There was a positive correlation between serum values for perforin, caspase-3 and M-30 and the disease's severity criteria such as aspartate aminotransferase and/or alanine aminotransferase. The serum levels of all these markers were negatively correlated with disease severity criteria such as the platelet count. Conclusions: In this study, we concluded that the interactions of cytolytic granules containing perforin and caspase cascade and Fas-FasL may play an important role in the pathogenesis of CCHF in children. | en_US |
dc.description.sponsorship | Cumhuriyet University BAP [T-539] | en_US |
dc.description.sponsorship | This study was supported by the Cumhuriyet University BAP with project number: T-539. The authors thank the Refik Saydam National Public Health Agency, a national reference laboratory in Turkey, for testing the serum samples. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.isversionof | 10.1097/INF.0000000000000530 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | perforin | en_US |
dc.subject | soluble Fas ligand | en_US |
dc.subject | caspase-3 | en_US |
dc.subject | M-30 | en_US |
dc.subject | apoptosis | en_US |
dc.subject | children | en_US |
dc.subject | Crimean-Congo hemorrhagic fever | en_US |
dc.title | Evaluation of Serum Perforin, Caspase-3, sFasL and M-30 Levels as Apoptotic Markers in Children With Crimean-Congo Hemorrhagic Fever | en_US |
dc.type | article | en_US |
dc.relation.journal | PEDIATRIC INFECTIOUS DISEASE JOURNAL | en_US |
dc.contributor.department | [Guven, Ahmet S. -- Kaya, Ali -- Oflaz, Mehmet B. -- Bolat, Fatih -- Cevit, Omer -- Icagasioglu, Fusun D.] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Uysal, Elif B.] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Tuzcu, Nevin] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Oflaz, Mehmet Burhan -- 0000-0003-1515-4654 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 213 | en_US |
dc.identifier.startpage | 208 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |