dc.contributor.author | Kucuk, A. | |
dc.contributor.author | Uslu, A. U. | |
dc.contributor.author | Ugan, Y. | |
dc.contributor.author | Bagcaci, S. | |
dc.contributor.author | Karahan, A. Y. | |
dc.contributor.author | Akannut, A. | |
dc.contributor.author | Sahin, A. | |
dc.contributor.author | Kucuksen, S. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:25Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:25Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://dx.doi.org/10.4149/BLL_2015_142 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7998 | |
dc.description | WOS: 000367280800006 | en_US |
dc.description | PubMed ID: 26924141 | en_US |
dc.description.abstract | OBJECTIVE: Ankylosing spondylitis (AS) is a progressive chronic inflammatory disease mainly characterized by axial skeleton and sacroiliac joint involvement. We aimed to investigate the relation between neutrophil-to-lymphocyte ratio (NLR) and disease severity of AS and to explore its availability in clinical practice. METHODS: A total of 102 AS patients and 60 individuals who were age- and gender-compatible with the control group were included into the study. Patients were divided into 2 groups according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores. Patients with BASDAI scores <4 were considered to be having mild disease activity, whereas those with scores 4 were considered to be displaying severe disease activity. Hemogram test during the diagnosis, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and other laboratory values of the control group were recorded. RESULTS: NLR was observed to be higher in AS patients compared to the controls (2.47 +/- 1.33 and 1.72 +/- 0.47; respectively; p<0.0001). NLR was observed to be significantly higher in severe AS disease activity compared to the mild AS disease activity (2.72 +/- 1.41, 2.20 +/- 1.19; respectively; p = 0.001). NLR had statistical significant differences between mild disease activity compared to the controls (2.20 +/- 1.19 and 1.72 +/- 0.47, respectively; p = 0.263). There was a positive correlation between NLR and BASDAI (r = 0.193, p = 0.041). The performance of NLR evaluating the disease severity by Roc analysis had sensitivity of 69%, specificity of 54% (cut-off value 1.91), and AUC of 0.652 (95% Cl, 0.549-0.755) (p = 0.006). CONCLUSIONS: NLR may be a simple and inexpensive marker to indicate disease activity in patients with AS in daily clinical practice (Tab. 3, Fig. 3, Ref. 25). Text in PDF www.elis.sk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | COMENIUS UNIV | en_US |
dc.relation.isversionof | 10.4149/BLL_2015_142 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ankylosing spondylitis | en_US |
dc.subject | BASDAI | en_US |
dc.subject | disease | en_US |
dc.subject | neutrophil-to-lymphocyte ratio | en_US |
dc.subject | severity | en_US |
dc.title | Neutrophil-to-lymphocyte ratio is involved in the severity of ankylosing spondylitis | en_US |
dc.type | article | en_US |
dc.relation.journal | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | en_US |
dc.contributor.department | [Kucuk, A.] Necmettin Erbakan Univ, Div Rheumatol, Dept Internal Med, Konya, Turkey -- [Uslu, A. U.] Kangal State Hosp, Dept Internal Med, Sivas, Turkey -- [Ugan, Y.] Sanliurfa Res & Educ Hosp, Div Rheumatol, Sanliurfa, Turkey -- [Bagcaci, S. -- Karahan, A. Y. -- Kucuksen, S.] Necmettin Erbakan Univ, Div Phys Med & Rehabil, Konya, Turkey -- [Akannut, A.] Necmettin Erbakan Univ, Fac Med, Konya, Turkey -- [Sahin, A.] Cumhuriyet Univ, Dept Intemal Med Rheumatol, Fac Med, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | karahan, ali yavuz -- 0000-0001-8142-913X | en_US |
dc.identifier.volume | 116 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.endpage | 725 | en_US |
dc.identifier.startpage | 722 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |