dc.contributor.author | Karakus, Gulderen | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:28Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:28Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1309-0801 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8022 | |
dc.description | WOS: 000361222900006 | en_US |
dc.description.abstract | Poly(maleic anhydride-co-styrene) (MAST), poly(maleic anhydride-co-vinyl acetate) (MAVA), poly(maleic anhydride-co-methyl methacrylate) (MAMMA), poly(maleic anhydride-co-allyl phenyl ether) (MAAFE) and poly(maleic anhydride-alt-acrylic acid) (MAAA) copolymers were synthesized by free radical chain polymerization reaction. Modification/derivatization of the copolymers with active pharmaceutical ingredients, in amine form (-NH2), was performed by the ring opening reaction. Structural characterization of the copolymers and the conjugated products was carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (H-1-NMR). The FTIR and H-1-NMR spectra, confirmed that pharmaceutically active agents were covalently bonded to the MAVA copolymer in a succesfull manner. Furthermore cytotoxicity on healthy fibroblast cell lines, antiproliferative activity on cancer cell lines and antibacterial activity on bacterial strains were also investigated in-vitro for synthesized conjugates. MAVA copolymer was also selected the most suitable carrier for modification/derivaritization process by comparing its affinity to the pharmaceutically active agents. | en_US |
dc.language.iso | tur | en_US |
dc.publisher | MARMARA UNIV, FAC PHARMACY | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Copolymer modification | en_US |
dc.subject | ring opening reaction | en_US |
dc.subject | antiproliferative activity | en_US |
dc.subject | antibacterial activity | en_US |
dc.subject | structural characterization | en_US |
dc.title | Derivatization of Some Maleic Anhydride Containing Copolymers with Amine Functionalized Pharmaceutical Active Substances, Structural Characterizations and Biological Activities | en_US |
dc.type | article | en_US |
dc.relation.journal | MARMARA PHARMACEUTICAL JOURNAL | en_US |
dc.contributor.department | Cumhuriyet Univ, Eczacilik Fak, Farmasotik Kimya Anabilim Dali, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 125 | en_US |
dc.identifier.startpage | 121 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |