Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis
dc.contributor.author | Balkan, Ilker Inanc | |
dc.contributor.author | Batirel, Ayse | |
dc.contributor.author | Karabay, Oguz | |
dc.contributor.author | Agalar, Canan | |
dc.contributor.author | Akalin, Serife | |
dc.contributor.author | Alici, Ozlem | |
dc.contributor.author | Alp, Emine | |
dc.contributor.author | Altay, Fatma Aybala | |
dc.contributor.author | Altin, Nilgun | |
dc.contributor.author | Arslan, Ferhat | |
dc.contributor.author | Aslan, Turan | |
dc.contributor.author | Bekiroglu, Nural | |
dc.contributor.author | Cesur, Salih | |
dc.contributor.author | Celik, Aygul Dogan | |
dc.contributor.author | Dogan, Mustafa | |
dc.contributor.author | Durdu, Bulent | |
dc.contributor.author | Duygu, Fazilet | |
dc.contributor.author | Engin, Aynur | |
dc.contributor.author | Engin, Derya Ozturk | |
dc.contributor.author | Gonen, Ibak | |
dc.contributor.author | Guciu, Ertugrul | |
dc.contributor.author | Guven, Tumer | |
dc.contributor.author | Hatipogiu, Cigdem Ataman | |
dc.contributor.author | Hosoglu, Salih | |
dc.contributor.author | Karahocagil, Mustafa Kasim | |
dc.contributor.author | Kilic, Aysegul Ulu | |
dc.contributor.author | Ormen, Bahar | |
dc.contributor.author | Ozdemir, Davut | |
dc.contributor.author | Ozer, Serdar | |
dc.contributor.author | Oztoprak, Nefise | |
dc.contributor.author | Sezak, Nurbanu | |
dc.contributor.author | Turhan, Vedat | |
dc.contributor.author | Turker, Nesrin | |
dc.contributor.author | Yilmaz, Hava | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:34Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:34Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0253-7613 | |
dc.identifier.issn | 1998-3751 | |
dc.identifier.uri | https://dx.doi.org/10.4103/0253-7613.150383 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8056 | |
dc.description | WOS: 000349144300018 | en_US |
dc.description | PubMed ID: 25821319 | en_US |
dc.description.abstract | Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MEDKNOW PUBLICATIONS & MEDIA PVT LTD | en_US |
dc.relation.isversionof | 10.4103/0253-7613.150383 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Blood stream infection | en_US |
dc.subject | colistin | en_US |
dc.subject | monotherapy | en_US |
dc.subject | multi drug resistant Acinetobacter spp | en_US |
dc.title | Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis | en_US |
dc.type | article | en_US |
dc.relation.journal | INDIAN JOURNAL OF PHARMACOLOGY | en_US |
dc.contributor.department | [Balkan, Ilker Inanc] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey -- [Batirel, Ayse -- Ozer, Serdar] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Istanbul, Turkey -- [Agalar, Canan -- Alici, Ozlem] Fatih Sultan Mehmet Educ & Res Hosp, Istanbul, Turkey -- [Arslan, Ferhat] Istanbul Medipol Univ, Fac Med, Istanbul, Turkey -- [Aslan, Turan] Bezmi Alem Univ, Fac Med, Istanbul, Turkey -- [Engin, Derya Ozturk] Haydarpasa Numune Educ & Res Hosp, Istanbul, Turkey -- [Bekiroglu, Nural] Marmara Univ, Fac Med, Istanbul, Turkey -- [Durdu, Bulent] Bakirkoy Sadi Konuk Educ & Res Hosp, Istanbul, Turkey -- [Turhan, Vedat] GATA Haydarpasa Educ & Res Hosp, Istanbul, Turkey -- [Karabay, Oguz -- Guciu, Ertugrul] Sakarya Univ, Fac Med, Sakarya, Turkey -- [Akalin, Serife] Pamukkale Univ, Fac Med, Denizli, Turkey -- [Alp, Emine -- Kilic, Aysegul Ulu] Erciyes Univ, Fac Med, Kayseri, Turkey -- [Altay, Fatma Aybala] Diskapi Educ & Res Hosp, Ankara, Turkey -- [Altin, Nilgun -- Cesur, Salih] Ankara Etlik Educ & Res Hosp, Ankara, Turkey -- [Celik, Aygul Dogan] Trakya Univ, Fac Med, Edirne, Turkey -- [Dogan, Mustafa] Namik Kemal Univ, Fac Med, Tekirdag, Turkey -- [Duygu, Fazilet] Gaziosmanpasa Univ, Fac Med, Tokat, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Fac Med, Sivas, Turkey -- [Gonen, Ibak] Suleyman Demirel Univ, Fac Med, TR-32200 Isparta, Turkey -- [Guven, Tumer] Ankara Ataturk Educ & Res Hosp, Ankara, Turkey -- [Hatipogiu, Cigdem Ataman] Ankara Educ & Res Hosp, Ankara, Turkey -- [Hosoglu, Salih] Dicle Univ, Fac Med, Diyarbakir, Turkey -- [Karahocagil, Mustafa Kasim] Yuzuncu Yil Univ, Fac Med, Van, Turkey -- [Ormen, Bahar] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey -- [Ozdemir, Davut -- Sezak, Nurbanu -- Turker, Nesrin] Duzce Univ, Educ & Res Hosp, Duzce, Turkey -- [Oztoprak, Nefise] Antalya Educ & Res Hosp, Antalya, Turkey -- [Yilmaz, Hava] Ondokuz Mayis Univ, Fac Med, Samsun, Turkey | en_US |
dc.contributor.authorID | Durdu, Bulent -- 0000-0002-0244-4006; Karabay, Oguz -- 0000-0003-0502-432X; altay, fatma aybala -- 0000-0002-7149-2968 | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 100 | en_US |
dc.identifier.startpage | 95 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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