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dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorBatirel, Ayse
dc.contributor.authorKarabay, Oguz
dc.contributor.authorAgalar, Canan
dc.contributor.authorAkalin, Serife
dc.contributor.authorAlici, Ozlem
dc.contributor.authorAlp, Emine
dc.contributor.authorAltay, Fatma Aybala
dc.contributor.authorAltin, Nilgun
dc.contributor.authorArslan, Ferhat
dc.contributor.authorAslan, Turan
dc.contributor.authorBekiroglu, Nural
dc.contributor.authorCesur, Salih
dc.contributor.authorCelik, Aygul Dogan
dc.contributor.authorDogan, Mustafa
dc.contributor.authorDurdu, Bulent
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorEngin, Aynur
dc.contributor.authorEngin, Derya Ozturk
dc.contributor.authorGonen, Ibak
dc.contributor.authorGuciu, Ertugrul
dc.contributor.authorGuven, Tumer
dc.contributor.authorHatipogiu, Cigdem Ataman
dc.contributor.authorHosoglu, Salih
dc.contributor.authorKarahocagil, Mustafa Kasim
dc.contributor.authorKilic, Aysegul Ulu
dc.contributor.authorOrmen, Bahar
dc.contributor.authorOzdemir, Davut
dc.contributor.authorOzer, Serdar
dc.contributor.authorOztoprak, Nefise
dc.contributor.authorSezak, Nurbanu
dc.contributor.authorTurhan, Vedat
dc.contributor.authorTurker, Nesrin
dc.contributor.authorYilmaz, Hava
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:56:34Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:56:34Z
dc.date.issued2015
dc.identifier.issn0253-7613
dc.identifier.issn1998-3751
dc.identifier.urihttps://dx.doi.org/10.4103/0253-7613.150383
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8056
dc.descriptionWOS: 000349144300018en_US
dc.descriptionPubMed ID: 25821319en_US
dc.description.abstractObjectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.en_US
dc.language.isoengen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.isversionof10.4103/0253-7613.150383en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood stream infectionen_US
dc.subjectcolistinen_US
dc.subjectmonotherapyen_US
dc.subjectmulti drug resistant Acinetobacter sppen_US
dc.titleComparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysisen_US
dc.typearticleen_US
dc.relation.journalINDIAN JOURNAL OF PHARMACOLOGYen_US
dc.contributor.department[Balkan, Ilker Inanc] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey -- [Batirel, Ayse -- Ozer, Serdar] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Istanbul, Turkey -- [Agalar, Canan -- Alici, Ozlem] Fatih Sultan Mehmet Educ & Res Hosp, Istanbul, Turkey -- [Arslan, Ferhat] Istanbul Medipol Univ, Fac Med, Istanbul, Turkey -- [Aslan, Turan] Bezmi Alem Univ, Fac Med, Istanbul, Turkey -- [Engin, Derya Ozturk] Haydarpasa Numune Educ & Res Hosp, Istanbul, Turkey -- [Bekiroglu, Nural] Marmara Univ, Fac Med, Istanbul, Turkey -- [Durdu, Bulent] Bakirkoy Sadi Konuk Educ & Res Hosp, Istanbul, Turkey -- [Turhan, Vedat] GATA Haydarpasa Educ & Res Hosp, Istanbul, Turkey -- [Karabay, Oguz -- Guciu, Ertugrul] Sakarya Univ, Fac Med, Sakarya, Turkey -- [Akalin, Serife] Pamukkale Univ, Fac Med, Denizli, Turkey -- [Alp, Emine -- Kilic, Aysegul Ulu] Erciyes Univ, Fac Med, Kayseri, Turkey -- [Altay, Fatma Aybala] Diskapi Educ & Res Hosp, Ankara, Turkey -- [Altin, Nilgun -- Cesur, Salih] Ankara Etlik Educ & Res Hosp, Ankara, Turkey -- [Celik, Aygul Dogan] Trakya Univ, Fac Med, Edirne, Turkey -- [Dogan, Mustafa] Namik Kemal Univ, Fac Med, Tekirdag, Turkey -- [Duygu, Fazilet] Gaziosmanpasa Univ, Fac Med, Tokat, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Fac Med, Sivas, Turkey -- [Gonen, Ibak] Suleyman Demirel Univ, Fac Med, TR-32200 Isparta, Turkey -- [Guven, Tumer] Ankara Ataturk Educ & Res Hosp, Ankara, Turkey -- [Hatipogiu, Cigdem Ataman] Ankara Educ & Res Hosp, Ankara, Turkey -- [Hosoglu, Salih] Dicle Univ, Fac Med, Diyarbakir, Turkey -- [Karahocagil, Mustafa Kasim] Yuzuncu Yil Univ, Fac Med, Van, Turkey -- [Ormen, Bahar] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey -- [Ozdemir, Davut -- Sezak, Nurbanu -- Turker, Nesrin] Duzce Univ, Educ & Res Hosp, Duzce, Turkey -- [Oztoprak, Nefise] Antalya Educ & Res Hosp, Antalya, Turkey -- [Yilmaz, Hava] Ondokuz Mayis Univ, Fac Med, Samsun, Turkeyen_US
dc.contributor.authorIDDurdu, Bulent -- 0000-0002-0244-4006; Karabay, Oguz -- 0000-0003-0502-432X; altay, fatma aybala -- 0000-0002-7149-2968en_US
dc.identifier.volume47en_US
dc.identifier.issue1en_US
dc.identifier.endpage100en_US
dc.identifier.startpage95en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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