dc.contributor.author | Can, Hatice Kaplan | |
dc.contributor.author | Karakus, Gulderen | |
dc.contributor.author | Tuzcu, Nevin | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:48Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:48Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0170-0839 | |
dc.identifier.issn | 1436-2449 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s00289-014-1230-2 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8134 | |
dc.description | WOS: 000343720300010 | en_US |
dc.description.abstract | Water-soluble maleic anhydride-containing poly[maleic anhydride-alt-acrylic acid] (poly(MA-alt-AA) or MAAA) copolymer was synthesized by freer-adical chain polymerization reaction, in 1,4-dioxane in the presence of benzoyl peroxide, 0.1 %, as the radical initiator at 70 degrees C under a nitrogen atmosphere. The purified copolymer was then modified with an anti-external fungal and anti-cancer active agent, acriflavine (AF). The modification reaction was performed 48 h at 70 degrees C in dimethylformamide organic media, using triethylamine (TEA or Et3N) as the catalyst. The modified or conjugated copolymer/drug couple was named as MAAA/AF. Detailed structural characterization of the copolymer (MAAA) and modified product (MAAA/AF) was carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (H-1-NMR and C-13-NMR). The obtained FTIR, H-1-NMR, and C-13-NMR spectra confirmed that AF was successfully bound to the MAAA copolymer backbone by ring-opening reaction. Antimicrobial susceptibility of the MAAA, AF, and MAAA/AF was evaluated by Kirby Bauer Disc Diffusion method on Mueller-Hinton Agar using Enterecoccus faecium, Enterohaemorrhagic Escherichia coli (EHEC), Staphylococcus aureus and Listeria monocytogenes. Results obtained indicated that MAAA/AF had antibacterial activity on EHEC and S. aureus at 50, 40, and 30 mu g. A mechanism for MAAA and AF was then also suggested for the conjugation reaction. | en_US |
dc.description.sponsorship | Sciences Research Projects Foundation of Cumhuriyet University [F258] | en_US |
dc.description.sponsorship | This work was supported by Sciences Research Projects Foundation of Cumhuriyet University (Project No: F258). Structural characterizations were carried out at Hacettepe University, Ankara, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s00289-014-1230-2 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acriflavine agent | en_US |
dc.subject | Copolymer modification | en_US |
dc.subject | Poly[maleic anhydride-alt-acrylic acid] | en_US |
dc.subject | FTIR spectroscopy | en_US |
dc.subject | NMR spectroscopy | en_US |
dc.title | Synthesis, characterization and in vitro antibacterial assessments of a novel modified poly[maleic anhydride-alt-acrylic acid]/acriflavine conjugate | en_US |
dc.type | article | en_US |
dc.relation.journal | POLYMER BULLETIN | en_US |
dc.contributor.department | [Can, Hatice Kaplan] Hacettepe Univ, Div Polymer Chem, Dept Chem, Fac Sci, TR-06800 Ankara, Turkey -- [Karakus, Gulderen] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Chem, TR-58140 Sivas, Turkey -- [Tuzcu, Nevin] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | KARAKUS, Gulderen -- 0000-0003-2596-9208 | en_US |
dc.identifier.volume | 71 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.endpage | 2921 | en_US |
dc.identifier.startpage | 2903 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |