dc.contributor.author | Gokakin, Ali Kagan | |
dc.contributor.author | Atabey, Mustafa | |
dc.contributor.author | Deveci, Koksal | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Tuzcu, Mehmet | |
dc.contributor.author | Duger, Cevdet | |
dc.contributor.author | Topcu, Omer | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:58Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:58Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1306-696X | |
dc.identifier.uri | https://dx.doi.org/10.5505/tjtes.2014.39586 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8187 | |
dc.description | WOS: 000344217300002 | en_US |
dc.description | PubMed ID: 25541842 | en_US |
dc.description.abstract | BACKGROUND: Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of the present study was to evaluate the effects of different dosages of sildenafil in remote organs injury. METHODS: A total of thirty-two rats were randomly divided into four equal groups. The groups were designated as follows: Sham, Control, 10, and T20 mg/kg sildenafil treatment groups. Levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), VEGF receptor (Flt-1), activities of glutathione peroxidase (Gpx), levels of total antioxidative capacity (TAC), and total oxidant status (TOS) were measured in both tissues and serum, and a semi-quantitative scoring system was used for the evaluation of histopathological findings. RESULTS: Sildenafil increased levels of Gpx, and Flt-1, and decreased MDA and VEGF levels in tissues. Sildenafil also increased serum levels of TAC and Flt-I and decreased TOS, OSI, and VEGF. CONCLUSION: Sildenafil decreased inflammation scores in remote organs in histopathological evaluation. It has protective effects in severe burn-related remote organ injuries by decreasing oxidative stress and inflammation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TURKISH ASSOC TRAUMA EMERGENCY SURGERY | en_US |
dc.relation.isversionof | 10.5505/tjtes.2014.39586 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Remote organ injury | en_US |
dc.subject | scald burn | en_US |
dc.subject | sildenafil | en_US |
dc.title | The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study | en_US |
dc.type | article | en_US |
dc.relation.journal | ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY | en_US |
dc.contributor.department | [Gokakin, Ali Kagan -- Atabey, Mustafa -- Topcu, Omer] Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Deveci, Koksal -- Sancakdar, Enver] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Tuzcu, Mehmet] Cumhuriyet Univ, Fac Vet, Dept Pathol, TR-58140 Sivas, Turkey -- [Duger, Cevdet] Cumhuriyet Univ, Fac Med, Dept Anesthesiol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 327 | en_US |
dc.identifier.startpage | 319 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |