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dc.contributor.authorCandan, Ferhan
dc.contributor.authorYildiz, Gursel
dc.contributor.authorKayatas, Mansur
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:57:00Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:57:00Z
dc.date.issued2014
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-014-0711-4
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8193
dc.descriptionWOS: 000341430800022en_US
dc.descriptionPubMed ID: 24748065en_US
dc.description.abstractVascular access is vital for hemodialysis patients. A major factor that facilitates arteriovenous (AV) fistula failure is stenosis and thrombosis due to intimal hyperplasia developing in the venous segment of AV fistula. It has been reported that VEGF accelerated re-endothelialization, reduction in intimal thickening, and/or mural thrombus formed in the injured vascular structures. In this study, we aimed to identify the effect of the VEGF 936 gene polymorphism and vascular endothelial growth factor-A (VEGF-A) levels in the late period of AV fistula loss in hemodialysis patients. The study was carried out with a patient group of 42 individuals who experienced two or more fistula thrombosis in the late period after the AV fistula operation and also a control group of 38 patients who have not had any AV fistula thrombosis history for 3 years or more. All participants were assessed for VEGF-936C/T gene polymorphism and VEGF-A levels. VEGF-936C/T genotypes were determined in the large proportion in the control group (31.6 %), while VEGF-936C/C genotypes were determined in a large proportion in the patient group (90.5 %). Individuals carrying the VEGF-936C/C genotype had an increased risk of 5.54 for getting AV fistula thrombosis. The VEGF-A levels of patient group (27.3 +/- A 43.5 pg/ml) were significantly lower than those of the control group (70.7 +/- A 53.1 pg/ml). There is an increased risk of AV fistula thrombosis in individuals carrying the VEGF-936C/C genotype. The other renal replacement modalities should be considered in patients with this genotype. As a result, it will be possible to prevent the morbidity and mortality due to fistula failure.en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.relation.isversionof10.1007/s11255-014-0711-4en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAV fistula stenosisen_US
dc.subjectHemodialysisen_US
dc.subjectVEGF gene polymorphismen_US
dc.subjectVEGF-Aen_US
dc.titleRole of the VEGF 936 gene polymorphism and VEGF-A levels in the late-term arteriovenous fistula thrombosis in patients undergoing hemodialysisen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL UROLOGY AND NEPHROLOGYen_US
dc.contributor.department[Candan, Ferhan -- Kayatas, Mansur] Cumhuriyet Univ, Div Nephrol, Dept Internal Med, Fac Med, TR-58140 Sivas, Turkey -- [Yildiz, Gursel] Ataturk State Hosp, Div Nephrol, Dept Internal Med, TR-67030 Zonguldak, Turkeyen_US
dc.identifier.volume46en_US
dc.identifier.issue9en_US
dc.identifier.endpage1823en_US
dc.identifier.startpage1815en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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