dc.description.abstract | Aim: We investigated the clinicopathological features in patients with recurrent RCC within 5 years or more than 5 years after nephrectomy and determined predictors of survival and response treatment after recurrence. Materials and Methods: We retrospectively evaluated 144 patients with disease recurrence; 73 had recurrence more than 5 years after radical nephrectomy. We compared clinicopathological characteristics in patients with disease recurrence before vs. after 5 years. In addition, we investigated predictors of survival and response to treatment after recurrence. Results: Seventy-one patients (49%) were diagnosed with recurrence within 5 years after radical nephrectomy (early recurrence) and 73 patients (51%) were diagnosed with recurrence more than 5 years after radical nephrectomy (late recurrence). Fuhrman grade, tumor necrosis and lymphovascular invasion were statistically significantly different between the two groups (p<0.001, p=0.013, p=0.026, respectively). The late recurrence patients were significantly associated with the Memorial Sloan Kettering Cancer Center (MSKCC) favorable risk group compared to patients with early recurrence (p=0.001). From the time of disease recurrence, median Overall Survival (OS) was 36.0 (95% Confidence Interval (CI) 30.7-412) months in the late recurrence group, and 19 (95% CI 15.4-22.5) months in the early recurrence group (p=0.01). The median Progression Free Survival (PFS) was 6 (95% CI 3.87-8.12) months in the early recurrence group, and 18 (95% CI 15.4-20.5) months for the late recurrence group (p<0.001). Conclusion: Early recurrence was significantly associated with Fuhrman grade 3-4, tumor necrosis, lymphovascular invasion, MSKCC poor- risk group compared to patients with late recurrence. The study also demonstrated a potential prognostic value of late recurrence in terms of PFS and OS. | en_US |
dc.contributor.department | [Bozkurt, Oktay -- Inanc, Mevlude -- Karaca, Halit -- Ozkan, Metin] Erciyes Univ, Fac Med, Dept Med Oncol, TR-38035 Kayseri, Turkey -- [Hacibekiroglu, Ilhan -- Oksuzoglu, Berna] Trakya Univ, Dept Med Oncol, Fac Med, Trakya, Turkey -- [Esbah, Onur -- Durnali, Ayse] Ankara Oncol Res & Training Hosp, Ankara, Turkey -- [Seker, Metin] Cumhuriyet Univ, Dept Med Oncol, Fac Med, Sivas, Turkey -- [Ulas, Arife -- Demirci, Umut] Ankara Ataturk Res & Teaching Hosp, Ankara, Turkey -- [Aydin, Kubra] Dr Lutfi Kirdar Kartal Training & Res Hosp, Istanbul, Turkey -- [Uysal, Mukremin] Afyon Kocatepe Univ, Dept Med Oncol, Fac Med, Afyon, Turkey -- [Kucukoner, Mehmet] Dicle Univ, Fac Med, Dept Med Oncol, Diyarbakir, Turkey -- [Uncu, Dogan] Ankara Numune Res & Teaching Hosp, Ankara, Turkey -- [Ciltas, Aydin -- Tonyali, Onder] Gazi Univ, Dept Med Oncol, Fac Med, Ankara, Turkey -- [Unal, Olcun Umit] Dokuz Eylul Univ, Dept Med Oncol, Fac Med, Izmir, Turkey -- [Berk, Veli] Elazig Res & Teaching Hosp, Elazig, Turkey | en_US |