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dc.contributor.authorYilmaz, Abdulkerim
dc.contributor.authorAlagozlu, Hakan
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorArici, Sema
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:57:06Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:57:06Z
dc.date.issued2014
dc.identifier.issn1735-143X
dc.identifier.issn1735-3408
dc.identifier.urihttps://dx.doi.org/10.5812/hepatmon.11283
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8220
dc.descriptionWOS: 000344637600001en_US
dc.descriptionPubMed ID: 25067937en_US
dc.description.abstractBackground: The specific antiviral T cells provide CC chemokine receptor 5 (CCR5) for the immune response during the hepatitis C virus (HCV) infection. Heterogenous and/or homozygous 32 base pair deletion in CCR5 gene (CCR5 432 bpdel) leads to reduced protein expression. Objectives: In the current case control study, we aimed to compare the histopathological findings of liver to the CCR5 432 bpdel mutation profiles, expression and some other clinical findings in patients with chronic HCV infection. Materials and Methods: Multiple Strip Assay reverse hybridisation and Real Time PCR techniques were used to determine the germline CCR5 mutations and immunohistochemical technique was used to evaluate the gene expression in targer tissue biopsies. Results: Target CCR5 WT/WT, WT/ Delta 32, and Delta 32/ Delta 32 genotypes were observed in 91.4%, 8.6% and 0.0% for HCV positive patients and 98.3%, 1.7% and 0.0% for control group respectively. The histologic activity index(HAI) was significantly lower(4.0 +/- 1.0) in the mutated group than the non-mutated group (5.7 +/- 1.0). Decreased fibrosis levels were detected in HCV positive mutated group. Conclusions: Results showed that CCR5 polymorphism was more frequent in HCV positive patients than in healthy population in Turkish population. Current results also showed that mutated CCR5 signalling pathway due to CCR5-Delta32 may potentially result in subtle reduction of HCV specifity to the drug responses due to the positive impact on liver inflammation, fibrosis levels and liver destruction in HCV infection.en_US
dc.language.isoengen_US
dc.publisherKOWSAR PUBLen_US
dc.relation.isversionof10.5812/hepatmon.11283en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemokinesen_US
dc.subjectHepatitis C Virusen_US
dc.subjectInfectionen_US
dc.titleEffects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patientsen_US
dc.typearticleen_US
dc.relation.journalHEPATITIS MONTHLYen_US
dc.contributor.department[Yilmaz, Abdulkerim -- Alagozlu, Hakan] Cumhuriyet Univ, Dept Gastroenterol, Sivas, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Dept Med Genet, Sivas, Turkey -- [Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Dept Med Genet, Canakkale, Turkey -- [Arici, Sema] Cumhuriyet Univ, Dept Pathol, Sivas, Turkeyen_US
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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