dc.contributor.author | Deveci, Koksal | |
dc.contributor.author | Oflaz, Mehmet Burhan | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Uysal, Elif Bilge | |
dc.contributor.author | Guven, Ahmet Sami | |
dc.contributor.author | Kaya, Ali | |
dc.contributor.author | Alkan, Filiz | |
dc.contributor.author | Cevit, Omer | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:57:08Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:57:08Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0903-4641 | |
dc.identifier.issn | 1600-0463 | |
dc.identifier.uri | https://dx.doi.org/10.1111/apm.12209 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8230 | |
dc.description | WOS: 000338030400010 | en_US |
dc.description | PubMed ID: 24320760 | en_US |
dc.description.abstract | We aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years of age with a laboratory-confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non-severe group). The sIL-2r and endothelin-1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non-severe CCHF and the control group (p < 0.05). In addition, those with non-severe CCHF were also found to have a significantly higher sIL-2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL-2r and endothelin-1 levels, serum levels of both sIL-2r and endothelin-1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL-2r and endothelin-1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL-2r and endothelin-1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease. | en_US |
dc.description.sponsorship | Research Foundation Council of Cumhuriyet University [T-539] | en_US |
dc.description.sponsorship | The Research Foundation Council of Cumhuriyet University partly supported this study (Project No. T-539). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1111/apm.12209 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Crimean-Congo hemorrhagic fever | en_US |
dc.subject | soluble IL-2r | en_US |
dc.subject | endothelin-1 | en_US |
dc.title | Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever | en_US |
dc.type | article | en_US |
dc.relation.journal | APMIS | en_US |
dc.contributor.department | [Deveci, Koksal -- Sancakdar, Enver -- Alkan, Filiz] Cumhuriyet Univ, Fac Med, Dept Clin Biochem, TR-58140 Sivas, Turkey -- [Oflaz, Mehmet Burhan -- Guven, Ahmet Sami -- Kaya, Ali -- Cevit, Omer] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Clin Microbiol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Oflaz, Mehmet Burhan -- 0000-0003-1515-4654 | en_US |
dc.identifier.volume | 122 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.endpage | 647 | en_US |
dc.identifier.startpage | 643 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |