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dc.contributor.authorTerzi, Hatice
dc.contributor.authorKayatas, Mansur
dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorYildiz, Gursel
dc.contributor.authorCandan, Ferhan
dc.descriptionWOS: 000337949800013en_US
dc.descriptionPubMed ID: 24673399en_US
dc.description.abstractBackground: In this present study, we aimed to investigate the association between therapeutic outcomes and vascular endothelial growth factor (VEGF) G-1154A and C-936T gene polymorphisms in patients with glomerulonephritis. Methods: Thirty-eight patients with glomerulonephritis diagnosed by renal biopsy were included to the study. All patients had proteinuria at least 1 gram (g)/day in urine analysis. At the end of a yearly therapy, patients with proteinuria less than 0.5 g/day were accepted as in complete remission and they were termed as group 1. The patients with proteinuria over 0.5 g/day were accepted as in no remission and they were termed as group 2. Results: The mean age of patients in group 1 and group 2 was 35.88 +/- 13.80 years and 37.30 +/- 13.89 years, respectively. There were nine (50%) male and nine (50%) female patients in group 1. In group 2, seven (35%) male and 13 (65%) female patients were present. Although VEGF G-1154A (GG) gene polymorphism was found in 55% of group 2 patients, and 22.2% of group 1 patients, but the differences did not reach statistical significance. There were no statistical differences between groups in terms of other gene polymorphisms. Namely, we obtained no statistical differences between therapeutic outcomes and gene polymorphisms. Conclusions: There is a significant difference between groups in terms of VEGF G-1154A (GG) gene polymorphism, but the minority of the patient population has led to not to reach statistical significance. So, this gene polymorphism has to be investigated in larger studies.en_US
dc.subjectGene polymorphismen_US
dc.subjecttherapeutic outcomesen_US
dc.subjectvascular endothelial growth factoren_US
dc.titleThe association between therapeutic outcomes and VEGF G-1154A and C-936T gene polymorphisms in patients with glomerulonephritisen_US
dc.relation.journalRENAL FAILUREen_US
dc.contributor.department[Terzi, Hatice -- Korkmaz, Serdal] Cumhuriyet Univ, Dept Hematol, Fac Med, TR-58140 Sivas, Turkey -- [Kayatas, Mansur -- Candan, Ferhan] Cumhuriyet Univ, Dept Nephrol, Fac Med, TR-58140 Sivas, Turkey -- [Yildiz, Gursel] Ataturk State Hosp, Dept Nephrol, Zonguldak, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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