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dc.contributor.authorBostanci, Vildan
dc.contributor.authorToker, Hulya
dc.contributor.authorSenel, Soner
dc.contributor.authorOzdemir, Hakan
dc.contributor.authorAydin, Huseyin
dc.descriptionWOS: 000335648800017en_US
dc.descriptionPubMed ID: 23826647en_US
dc.description.abstractBackground: The aim of this study is to investigate the impact of periodontal status on oxidant/antioxidant status in patients with chronic periodontitis (CP) who experienced familial Mediterranean fever (FMF) and their response to non-surgical periodontal therapy. Methods: Data were obtained from 13 patients with FMF with generalized CP (FMF-CP), 15 systemically healthy patients with generalized CP, 15 systemically and periodontal healthy controls (HCs), and 14 periodontally healthy patients with FMF (FMF-HC). Each participant's total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in their gingival crevicular fluid (GCF) and serum were recorded. Probing depth, clinical attachment level, and gingival and plaque indices in each participant were also measured. The GCF and clinical parameters at baseline and 6 weeks after periodontal treatment were recorded. Results: The study showed statistically significant improvement of clinical parameters in both FMF-CP and CP groups after periodontal treatment. The baseline GCF-TOS and OSI levels were significantly higher in the CP group compared with the FMF-CP group (P < 0.05). After periodontal treatment, the GCF-TOS levels were significantly reduced in members of the FMF-CP group (P < 0.05). The GCF-TAS levels in members of the FMF-CP group were significantly higher than those of members of the HC group at baseline (P < 0.05). Serum-TAS levels in the FMF-CP group were significantly higher than those in the CP and HC groups at baseline (P < 0.05). The GCF-TOS level in the FMF-CP group was significantly higher than that in the FMF-HC group at baseline and 6 weeks. However, there were no significant differences in the serum-TOS and serum-OSI levels of those in the FMF-CP and CP groups at baseline and 6 weeks (P > 0.05). Conclusion: The results of the present study show that patients with FMF-CP displayed reduced oxidative stress and increased antioxidant status compared with those in the CP and HC groups.en_US
dc.titleEffect of Chronic Periodontitis on Serum and Gingival Crevicular Fluid Oxidant and Antioxidant Status in Patients With Familial Mediterranean Fever Before and After Periodontal Treatmenten_US
dc.contributor.department[Bostanci, Vildan -- Toker, Hulya -- Ozdemir, Hakan] Cumhuriyet Univ, Fac Dent, Dept Periodontol, TR-58140 Sivas, Turkey -- [Senel, Soner] Erciyes Univ, Fac Med, Dept Rheumatol, Kayseri, Turkey -- [Aydin, Huseyin] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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