EFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII BACTEREMIA/SEPSIS
dc.contributor.author | Karabay, Oguz | |
dc.contributor.author | Batirel, Ayse | |
dc.contributor.author | Balkan, Ilker Inanc | |
dc.contributor.author | Agalar, Canan | |
dc.contributor.author | Akalin, Serife | |
dc.contributor.author | Alici, Ozlem | |
dc.contributor.author | Alp, Emine | |
dc.contributor.author | Alta, F. Aybala | |
dc.contributor.author | Altin, N. | |
dc.contributor.author | Arslan, Ferhat | |
dc.contributor.author | Aslan, Turan | |
dc.contributor.author | Bekiroglu, Nural | |
dc.contributor.author | Cesur, Salim | |
dc.contributor.author | Celik, Aygul Dogan | |
dc.contributor.author | Dogan, Mustafa | |
dc.contributor.author | Durdu, Bulent | |
dc.contributor.author | Duygu, Fazilet | |
dc.contributor.author | Engin, Aynur | |
dc.contributor.author | Engin, Derya Ozturk | |
dc.contributor.author | Gonen, Ibak | |
dc.contributor.author | Guclui, Ertugrul | |
dc.contributor.author | Guven, Tumer | |
dc.contributor.author | Hatipoglu, Cigdem Ataman | |
dc.contributor.author | Hosoglu, Salih | |
dc.contributor.author | Karahocagil, Mustafa | |
dc.contributor.author | Kilic, Aysegul Ulu | |
dc.contributor.author | Ormen, Bahar | |
dc.contributor.author | Ozdemir, Davut | |
dc.contributor.author | Ozer, Serdal | |
dc.contributor.author | Oztoprak, Nefise | |
dc.contributor.author | Sezak, Nurbanu | |
dc.contributor.author | Turhan, Vedat | |
dc.contributor.author | Turker, N. | |
dc.contributor.author | Yilmaz, Hava | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:57:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:57:40Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0393-6384 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8351 | |
dc.description | WOS: 000364114800027 | en_US |
dc.description.abstract | Objective: This retrospective study aimed to investigate the efficacies of colistin and non-colistin monotherapies in multi-drug resistant Acinetobacter baumannii bacteremia (MDR-AB). Materials and methods: Cases with MDR-AB from 27 tertiary-referral hospitals between January 2009 and December 2012 were included. Patients' data that were on either colistin monotherapy (CM) or non-colistin monotherapy (NCM) were compared. Mortality on Day 14 was the primary endpoint, whereas microbiological eradication and clinical outcome were the secondary ones. Results: Eighty-four cases were included in the study with 36 being in the CM group and 48 in the NCM group. Thirty-eight (452%) cases were male and the mean age was 602 years. The mean durations of pre-MDR-AB hospital stay and intensive care unit stay were 25.8 days and 20.9 days, respectively. All of the cases had fever (>38 degrees C). The mean Pitt bacteremia score (PBS) of the patients was calculated as 6.8, APACHE 2 score as 18.9 and the Charlson co-morbidity index (CCI) as 3.7 (CM: 3.6 vs. NCM: 3.9). Twenty (55.6%) cases in the CM group and 26 cases in the NCM group (542%) (p=0.81) died; 9 cases in the CM group (25%) and 16 cases in the NCM group (33 3%) had treatment failure (P=0.55). Bacteriological eradication was achieved in 20 (55.6%) cases in the CM group and in 36 cases (75%) in the NCM group (P=0.061). Conclusions: No significant difference could be identified between the colistin monotherapy and non-colistin monotherapy options in MDR-AB cases with respect to the results of efficacy and 14-day mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | CARBONE EDITORE | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acinetobacter baumannii | en_US |
dc.subject | bacteremia | en_US |
dc.subject | colistin | en_US |
dc.subject | monotherapy | en_US |
dc.subject | multi-drug resistant | en_US |
dc.subject | sepsis | en_US |
dc.title | EFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII BACTEREMIA/SEPSIS | en_US |
dc.type | article | en_US |
dc.relation.journal | ACTA MEDICA MEDITERRANEA | en_US |
dc.contributor.department | [Karabay, Oguz] Sakarya Univ, Hlth Sci Inst, Infect Dis & Clin Microbiol, TR-54000 Sakarya, Turkey -- [Batirel, Ayse] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Balkan, Ilker Inanc -- Ozer, Serdal] Istanbul Univ, Cerrahpasa Med Fac, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Agalar, Canan -- Alici, Ozlem] Fatih Sultan Mehmet Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Akalin, Serife] Pamukkale Univ, Fac Med, Infect Dis & Clin Microbiol, Denizli, Turkey -- [Alp, Emine -- Kilic, Aysegul Ulu] Erciyes Univ, Fac Med, Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Alta, F. Aybala] Diskapi Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Altin, N. -- Cesur, Salim] Ankara Etlik Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Arslan, Ferhat] Istanbul Medipol Univ, Fac Med, Infect Dis, Istanbul, Turkey -- [Aslan, Turan] Bezmi Alem Univ, Fac Med, Infect Dis, Istanbul, Turkey -- [Bekiroglu, Nural] Marmara Univ, Fac Med, Biostat, Istanbul, Turkey -- [Celik, Aygul Dogan] Trakya Univ, Fac Med, Infect Dis, Edirne, Turkey -- [Dogan, Mustafa] Namik Kemal Univ, Fac Med, Infect Dis & Clin Microbiol, Tekirdag, Turkey -- [Durdu, Bulent] Bakirkoy Sadi Konuk Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Duygu, Fazilet] Gaziosmanpasa Univ, Fac Med, Infect Dis & Clin Microbiol, Tokat, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Fac Med, Infect Dis & Clin Microbiol, Sivas, Turkey -- [Engin, Derya Ozturk] Haydarpasa Numune Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Gonen, Ibak] Suleyman Demirel Univ, Fac Med, Infect Dis & Clin Microbiol, TR-32200 Isparta, Turkey -- [Guven, Tumer] Ankara Ataturk Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Hatipoglu, Cigdem Ataman] Ankara Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Hosoglu, Salih] Dicle Univ, Fac Med, Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karahocagil, Mustafa] Yuzuncu Yil Univ, Fac Med, Infect Dis & Clin Microbiol, Van, Turkey -- [Ormen, Bahar] Izmir Ataturk Educ & Res Hosp, Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ozdemir, Davut -- Sezak, Nurbanu -- Turker, N.] Duzce Univ, Educ & Res Hosp, Infect Dis & Clin Microbiol, Duzce, Turkey -- [Oztoprak, Nefise] Antalya Educ & Res Hosp, Infect Dis & Clin Microbiol, Antalya, Turkey -- [Turhan, Vedat] GATA Haydarpasa Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, Hava] Ondokuz Mayis Univ, Fac Med, Infect Dis & Clin Microbiol, Samsun, Turkey | en_US |
dc.contributor.authorID | Karabay, Oguz -- 0000-0003-0502-432X | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 1143 | en_US |
dc.identifier.startpage | 1137 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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