dc.contributor.author | Yilmaz, Meral | |
dc.contributor.author | Kacan, Turgut | |
dc.contributor.author | Sari, Ismail | |
dc.contributor.author | Kilickap, Saadettin | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:57:46Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:57:46Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1513-7368 | |
dc.identifier.uri | https://dx.doi.org/10.7314/APJCP.2014.15.15.6333 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8373 | |
dc.description | WOS: 000343723600063 | en_US |
dc.description | PubMed ID: 25124620 | en_US |
dc.description.abstract | Background: In this case-control study, we aimed to investigate the relationship between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lung cancer. Materials and Methods: Total 200 individuals including 100 patients with lung cancer and 100 controls were analyzed. Genotyping of MTHFR C677T was performed using PCR and RFLP methods. Results: The majority of the patients were men and 90% were smokers. We found that the risk ratio for development of LC was 13-times higher in smokers compared with non-smokers between patient and control groups in our study (OR:13.5, 95% CI:6.27-29.04, p:0.0001). Besides, the risk ratio for development of LC was nine times higher in individuals with cancer history in their family than those without cancer history (OR:9.65, 95% CI:2.79-33.36; p:0.0001). When genotype distributions and allele frequencies were analyzed in the study groups, no significant difference was apparent (chi(2):0.53, p=0.76). In addition, no correlation between genotypes of MTHFR C677T polymorphism and histological type of LC was found (chi(2):0.99, p=0.60). Conclusions: These results suggest that there was no association between the MTHFR C677T polymorphism and lung cancer in the Turkish population. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ASIAN PACIFIC ORGANIZATION CANCER PREVENTION | en_US |
dc.relation.isversionof | 10.7314/APJCP.2014.15.15.6333 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Lung cancer | en_US |
dc.subject | risk factor | en_US |
dc.subject | methylenetetrahydrofolate reductase gene | en_US |
dc.subject | polymorphism | en_US |
dc.title | Lack of Association between the MTHFR C677T Polymorphism and Lung Cancer in a Turkish Population | en_US |
dc.type | article | en_US |
dc.relation.journal | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | en_US |
dc.contributor.department | [Yilmaz, Meral] Cumhuriyet Univ, Fac Med, Dept Res Ctr, Sivas, Turkey -- [Kacan, Turgut] Cumhuriyet Univ, Fac Med, Dept Med Oncol, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Fac Med, Dept Med Biochem, Sivas, Turkey -- [Kilickap, Saadettin] Hacettepe Univ, Fac Med, Dept Med Oncol, TR-06100 Ankara, Turkey | en_US |
dc.contributor.authorID | Sari, Ismail -- 0000-0003-3732-2102 | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 15 | en_US |
dc.identifier.endpage | 6337 | en_US |
dc.identifier.startpage | 6333 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |