dc.contributor.author | Dogan, N. | |
dc.contributor.author | Gokakin, A. K. | |
dc.contributor.author | Koyuncu, A. | |
dc.contributor.author | Bagcivan, I | |
dc.contributor.author | Aydin, C. | |
dc.contributor.author | Topcu, O. | |
dc.contributor.author | Yildirim, S. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:57:52Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:57:52Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://dx.doi.org/10.4149/BLL_2014_067 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8393 | |
dc.description | WOS: 000339087300004 | en_US |
dc.description | PubMed ID: 25023423 | en_US |
dc.description.abstract | Background: The aim of this study is to compare the motility of Roux limb with that of normal segment. Materials and methods: Rats were divided into 3 equal groups as control, Roux-en-Y (Group A) and Roux-en-Y with vagotomy (Group B). Only midline incision and manipulations were applied in control group. Following distal gastrectomy, Roux-en-Y reconstruction was applied in Group A, while vagotomy Roux-en-Y gastrojejunostonny was applied in Group B. Rats were sacrificed 1 month later by cervical dislocations under anesthesia. The obtained jejunal segments were cut into four equal parts. The bath was 37 degrees C warm while 95 % 02 and 5 % CO2 gases were supplied in 10 ml bicarbonate Krebs' solution. Results: KCl responses were similar in all three groups. Acetylcholine contraction responses in the vagotomy and non-vagotomy Roux-en-Y groups was higher than in those in control group significantly (p < 0.05). This response in vagotomy Roux-en-Y group was also higher than that in non-vagotomy group (p < 0.05). The induced electrical field stimulation contraction response in the vagotomy + Roux-en-Y group was lower than those in control group and non-vagotomy group (p < 0.05). Conclusions: These results show that muscarinic receptor density and/or function may increase after vagotomy and non-vagotomy group operation, and vagotomy may contribute to this increase. The decrease in electrical signal response in vagotomy Roux-en-Y group may depend on the decrease in acetylcholine oscillation from the cholinergic nerve ending (Tab. 1, Fig. 5, Ref. 25). Text in PDF www.elis.sk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | COMENIUS UNIV | en_US |
dc.relation.isversionof | 10.4149/BLL_2014_067 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Roux-en-Y | en_US |
dc.subject | Roux stasis syndrome | en_US |
dc.subject | acetylcholine | en_US |
dc.subject | electrical field stimulation | en_US |
dc.subject | jejunum | en_US |
dc.subject | motility | en_US |
dc.title | In vitro motility changes in Roux limb after Roux-en-Y reconstruction | en_US |
dc.type | article | en_US |
dc.relation.journal | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | en_US |
dc.contributor.department | [Gokakin, A. K.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Dogan, N. -- Gokakin, A. K. -- Koyuncu, A. -- Aydin, C. -- Topcu, O.] Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Bagcivan, I -- Yildirim, S.] Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 115 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 344 | en_US |
dc.identifier.startpage | 340 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |