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dc.contributor.authorOzgur, Aykut
dc.contributor.authorTutar, Yusuf
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:57:53Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:57:53Z
dc.date.issued2014
dc.identifier.issn1570-1646
dc.identifier.issn1875-6247
dc.identifier.urihttps://dx.doi.org/10.2174/1570164611666140415224635
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8395
dc.descriptionWOS: 000339257900002en_US
dc.description.abstractHeat shock protein 90 (Hsp90) is highly conserved chaperone protein which plays vital roles in stabilization, regulation and folding of client proteins in cancer cells. Client proteins are key macromolecules for carcinogenesis and their maintenance (stabilization and protection from aggregation and misfolding) is provided by Hsp90 chaperone activity. Hsp90 allows proliferation of cancer cells by keeping misfolded client proteins in their proper functional folded form and suppresses apoptotic pathways for cancer cell survival. For this purpose, Hsp90 inhibitors have become an important growing class of antitumor agents in pharmaceutical industry. To date, numerous compounds have been tested as anticancer drugs in preclinical and clinical studies. Hsp90 inhibitors may be categorized into two main classes: natural and synthetic inhibitors. In this review, we will discuss the general properties and structure of both natural inhibitors (geldanamycin, 17-AAG, 17-DMAG, herbimycin, radicicol, novobiocin, (-)-EGCG, derrubone, gedunin, celastrol and their derivatives) and synthetic inhibitors (purine scaffold inhibitors, pyrazole scaffold inhibitors, SNX-2112, STA9090 and their derivatives) along with their therapeutic strategies in many different cancer types.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA-GEBIP)en_US
dc.description.sponsorshipYT acknowledges Turkish Academy of Sciences (TUBA-GEBIP).en_US
dc.language.isoengen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.relation.isversionof10.2174/1570164611666140415224635en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectchaperoneen_US
dc.subjectclient proteinsen_US
dc.subjectgeldanamycinen_US
dc.subjectHsp90 inhibitorsen_US
dc.subjectHsp90en_US
dc.titleHeat Shock Protein 90 Inhibitors in Oncologyen_US
dc.typearticleen_US
dc.relation.journalCURRENT PROTEOMICSen_US
dc.contributor.department[Ozgur, Aykut] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, Tokat, Turkey -- [Tutar, Yusuf] Cumhuriyet Univ, Fac Pharm, Dept Basic Sci, Div Biochem, Sivas, Turkeyen_US
dc.identifier.volume11en_US
dc.identifier.issue1en_US
dc.identifier.endpage16en_US
dc.identifier.startpage2en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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