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dc.contributor.authorErdem, Hakan
dc.contributor.authorInan, Asuman
dc.contributor.authorElaldi, Nazif
dc.contributor.authorTekin, Recep
dc.contributor.authorGulsun, Serda
dc.contributor.authorAtaman-Hatipoglu, Cigdem
dc.contributor.authorBeeching, Nicholas
dc.contributor.authorDeveci, Ozcan
dc.contributor.authorYalci, Aysun
dc.contributor.authorBolukcu, Sibel
dc.contributor.authorDagli, Ozgur
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:08Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:08Z
dc.date.issued2014
dc.identifier.issn0012-3692
dc.identifier.urihttps://dx.doi.org/10.1378/chest.13-0240
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8443
dc.descriptionWOS: 000329966300022en_US
dc.descriptionPubMed ID: 23907372en_US
dc.description.abstractBackground: Pulmonary involvement is a rare complication of brucellosis. We describe the largest series to date, to our knowledge, of patients with pulmonary brucellosis. Methods: This 10-year, retrospective, descriptive study involved 27 centers in Turkey, including all patients with brucellosis with confirmed respiratory system involvement. Results: Of 133 patients (67 men), 123 (92.5%) had acute infection (defined as, 2 months), with an overall mean +/- SD duration of symptoms of 33.9 +/- 8.5 days. The radiologic pattern of pulmonary disease was consolidation/lobar pneumonia in 91 patients (68.4%) and pleural effusion in 41 patients (30.8%), including 30 (22.5%) with both. Moreover, 23 patients (17.3%) had bronchitis (one with coexistent pneumonia), and 10 (7.5%) had nodular lung lesions (one with coexistent pneumonia and effusion). Blood culture results were positive in 56 of 119 patients, and all other cases were serologically confirmed. None of 60 sputum specimens and two of 19 pleural fluid samples (10.5%) yielded positive culture results for brucellosis. Other features of brucellosis, such as osteoarticular complications, were detected in 61 patients (45.9%); 59 (44.4%) had raised liver transaminase levels, and 59 (44.4%) had thrombocytopenia. Fifteen patients (11.3%) required management in an ICU for an average of 3.8 +/- 2.2 days. All patients responded to standard combination antimicrobial therapy for brucellosis with no deaths, although treatment regimens required modification in seven patients. Conclusions: Brucellosis with pulmonary involvement is rare but has a good prognosis following treatment with appropriate antibiotics. Many clues in the exposure history, presenting clinical features, and baseline blood tests should alert the clinician to consider brucellosis.en_US
dc.language.isoengen_US
dc.publisherAMER COLL CHEST PHYSICIANSen_US
dc.relation.isversionof10.1378/chest.13-0240en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleRespiratory System Involvement in Brucellosis The Results of the Kardelen Studyen_US
dc.typearticleen_US
dc.relation.journalCHESTen_US
dc.contributor.department[Erdem, Hakan] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Inan, Asuman -- Bolukcu, Sibel] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Tekin, Recep -- Deveci, Ozcan] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Gulsun, Serda] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Ataman-Hatipoglu, Cigdem] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Yalci, Aysun] Ankara Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-06100 Ankara, Turkey -- [Beeching, Nicholas] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England -- [Dagli, Ozgur] Gaziantep State Hosp, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkeyen_US
dc.contributor.authorIDmert, gurkan -- 0000-0002-3795-6394; Beeching, Nicholas -- 0000-0002-7019-8791; Elaldi, Nazif -- 0000-0002-9515-770Xen_US
dc.identifier.volume145en_US
dc.identifier.issue1en_US
dc.identifier.endpage+en_US
dc.identifier.startpage87en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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