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Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure
(BMC, 2016)
Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategies have failed ...
Impact of diuretic dosing on mortality in acute heart failure using a propensity-matched analysis
(OXFORD UNIV PRESS, 2011)
Aims Loop diuretics are recommended to treat congestion in heart failure (HF), despite limited quality evidence. High-dose (HD) loop diuretics seem to worsen outcomes in chronic HF, though; data for acute HF are scarce, ...
Mortality and acute exacerbation of COPD: a pilot study on the influence of myocardial injury
(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2017)
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Cardiohepatic interactions in heart failure
(TURKISH SOC CARDIOLOGY, 2013)
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Effect of precipitating factors of acute heart failure on readmission and long-term mortality
(WILEY PERIODICALS, INC, 2016)
AimsAcute heart failure (AHF) is one of the leading causes of unscheduled hospitalization and is associated with frequent readmissions and substantial mortality. Precipitating factors of AHF influence short-term mortality, ...
Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
(WILEY, 2017)
Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical ...
Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology
(WILEY, 2016)
Acute right ventricular (RV) failure is a complex clinical syndrome that results from many causes. Research efforts have disproportionately focused on the failing left ventricle, but recently the need has been recognized ...
Practical approach to acute heart failure with algorithms
(TURKISH SOC CARDIOLOGY, 2009)
Acute heart failure syndrome is a heterogeneous group, which requires distinct therapeutic approaches. Diuretics and/or vasodilators for patients with high blood pressure and inotropic agents for patients with low left ...
Levosimendan: Molecular mechanisms and clinical implications Consensus of experts on the mechanisms of action of levosimendan
(ELSEVIER IRELAND LTD, 2012)
The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments. Over the years, significant preclinical and ...
In vivo and in vitro evidence for pleiotropic effects of levosimendan in the intensive care setting
(BIOMED CENTRAL LTD, 2011)
Levosimendan, in addition to its inotropic properties, could have anti-inflammatory and anti-oxidative properties, and can potentially decrease the deleterious effects of reactive oxygen species on the tissues. In their ...