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Therapeutic Targeting of microRNAs in Cancer: Future Perspectives
(WILEY-BLACKWELL, 2015)
The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types ...
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
(BENTHAM SCIENCE PUBL LTD, 2016)
Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ...
Effect of salt bridge on transcription activation of CRP-dependent lactose operon in Escherichia coli
(ELSEVIER SCIENCE INC, 2006)
Expression of catabolite-sensitive operons in Escherichia coli is cAMP-dependent and mediated through the CRP:cAMP complex binding to specific sequences in DNA. Five specific ionic or polar interactions occur in cAMP binding ...
CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands
(TAYLOR & FRANCIS LTD, 2016)
Carbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown ...
Therapeutic Proteins: A to Z
(BENTHAM SCIENCE PUBL LTD, 2013)
In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many ...
Heat shock proteins, substrate specificity and modulation of function
(BENTHAM SCIENCE PUBL LTD, 2006)
Hsp70 is a universally conserved essential protein chaperone. In addition to its roles in many cellular process, Hsp70 protects cells from stress by binding partially unfolded proteins. Therefore, Hsp70 prevents protein ...
Heat shock protein 70 purification and characterization from Cyprinion macrastomus macrastomus and Garra rufa obtusa
(PERGAMON-ELSEVIER SCIENCE LTD, 2012)
Organisms resist stress factors by common mechanisms at cellular and physiological levels. Heat shock proteins (Hsps) play an essential role as a protective mechanism against stressors, and Hsp70 has a central role in the ...
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
(PERGAMON-ELSEVIER SCIENCE LTD, 2013)
In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in ...
Isolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015)
Toxoplasma gondii is an intracellular parasitic protozoon which infects human and most warm-blooded animals. Almost one-third of the world's population is affected by life-threatening infection of T. gondii tachyzoites ...
Determination of Optimum Operation Parameters for Low-Intensity Pulsed Ultrasound and Low-Level Laser Based Treatment to Induce Proliferation of Osteoblast and Fibroblast Cells
(MARY ANN LIEBERT, INC, 2018)
Objective: The aim of this study was to determine the optimum operating parameters (pulse duration, energy levels, and application time) to promote induction of osteoblast and fibroblast cell proliferation and to maintain ...