dc.contributor.author | Yildiz, G. | |
dc.contributor.author | Magden, K. | |
dc.contributor.author | Abdulkerim, Y. | |
dc.contributor.author | Ozcicek, F. | |
dc.contributor.author | Hur, E. | |
dc.contributor.author | Candan, F. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:58:24Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:58:24Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0026-4806 | |
dc.identifier.issn | 1827-1669 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8491 | |
dc.description | WOS: 000331341600004 | en_US |
dc.description | PubMed ID: 24316914 | en_US |
dc.description.abstract | Aim. In this study, we compared estimated glomerular filtration rate (eGFR) calculated with the formulas of Cockcroft-Gault (C&G), Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Mayo Clinic Quadratic (Mayo Q) and, GFR (mGFR) that was scintigraphically measured with creatinine clearance (CrCl) and technetium-99m diethylene triamine penta-acetic acid (99mTc-DTPA). Objective of this study was to define the correlations between the formulas, provide a reliable method for measurement and estimation of GFR in daily clinical practice and demonstrate the potential errors. Methods. C&G, CKD-EPI, Mayo Q and MDRD eGFR of 84(37 males, 47 females) patients diagnosed with chronic kidney disease were calculated. Values of 99mTc-DTPA based on mGFR were compared with eGFR values of the formulas. Results. Significant correlations were found with the values of 99mTc-DTPA mGFR, CrCl, MDRD, CKD-EPI, Mayo Q and C&G eGFR. The highest correlation was found between LBM(lean body mass) corrected C&G, MDRD-6, Mayo Q and CKD-EPI eGFR. The best estimate was made with MDRD-6 in the cases with 99mTc-DTPA mGFR<30 mL/min/1.73 m(2) and with MDRD-4 in the cases with 99mTc-DTPA mGFR >= 30 mL/min/1.73 m(2), while the worst estimate was made with uncorrected C&G formula in both groups. Conclusion. All eGFR formulas can be used in daily clinical practice. However, using MDRD-6 in the cases with GFR<30 mL/min/1.73 m2 and MDRD-4 in the cases with GFR >= 30 mL/min/1.73m(2) as well as using LBM for C&G eGFR or correction according to LBM when AW (actual weight) is used, might provide a more accurate estimation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | EDIZIONI MINERVA MEDICA | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Renal insufficiency, chronic | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Glomerular filtration rate | en_US |
dc.title | Glomerular filtration rate: which method should we measure in daily clinical practice? | en_US |
dc.type | article | en_US |
dc.relation.journal | MINERVA MEDICA | en_US |
dc.contributor.department | [Yildiz, G.] Ataturk State Hosp, Zonguldak, Turkey -- [Magden, K. -- Hur, E.] Bulen Ecevit Univ, Zonguldak, Turkey -- [Abdulkerim, Y.] Gaziosmanpasa Univ, Sch Med, Tokat, Turkey -- [Ozcicek, F.] Erzincan Univ, Erzincan, Turkey -- [Candan, F.] Cumhuriyet Univ, Sivas, Turkey | en_US |
dc.identifier.volume | 104 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 623 | en_US |
dc.identifier.startpage | 613 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |