dc.contributor.author | Coskun, Kubra A. | |
dc.contributor.author | Ozgur, Aykut | |
dc.contributor.author | Otag, Begum | |
dc.contributor.author | Mungan, Mesut | |
dc.contributor.author | Tutar, Yusuf | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:58:28Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:58:28Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0929-8665 | |
dc.identifier.issn | 1875-5305 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8501 | |
dc.description | WOS: 000326985700002 | en_US |
dc.description | PubMed ID: 24261974 | en_US |
dc.description.abstract | Toxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of T. gondii can cause acute infection, and it is called toxoplasmosis. The development of latent bradyzoites from rapidly growing tachyzoites has been linked to cellular and environmental stresses which are associated with heat shock proteins (Hsps). Hsps play a protective role against stressors. Hsp40 is an important member of Hsp family and T. gondii has 36 predicted Hsp40 family members. Therefore, we studied the cloning and biochemical characterization of the T. gondii RH strain Hsp40 protein-Gok1. Hsp40 prevents protein aggregation and induce refolding. Consequently, Hsp40s may play essential roles in the mechanisms of bradyzoite development and survival in the host organism. Hsp40-Gok1 functional and structural properties may facilitate drug design and protein targeting against toxoplasmosis. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey, TUBITAK [110T928]; TUBA-GEBIP [2008-29] | en_US |
dc.description.sponsorship | The authors gratefully acknowledge the financial support received from the Scientific and Technological Research Council of Turkey, TUBITAK (Grant number 110T928) and partial support from TUBA-GEBIP for YT (2008-29). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BENTHAM SCIENCE PUBL LTD | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Heat Shock protein 40 | en_US |
dc.subject | Toxoplasma gondii | en_US |
dc.subject | protein folding | en_US |
dc.subject | protein aggregation | en_US |
dc.title | Heat Shock Protein 40-Gok1 Isolation from Toxoplasma gondii RH Strain | en_US |
dc.type | article | en_US |
dc.relation.journal | PROTEIN AND PEPTIDE LETTERS | en_US |
dc.contributor.department | [Coskun, Kubra A. -- Ozgur, Aykut] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, Tokat, Turkey -- [Otag, Begum] Cumhuriyet Univ, Grad Sch Nat & Appl Sci, Dept Bioengn, Sivas, Turkey -- [Mungan, Mesut] Publ Hlth Inst Turkey, Dept Communicable Dis, Ankara, Turkey -- [Tutar, Yusuf] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkey | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.endpage | 1301 | en_US |
dc.identifier.startpage | 1294 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |