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dc.contributor.authorCoskun, Kubra A.
dc.contributor.authorOzgur, Aykut
dc.contributor.authorOtag, Begum
dc.contributor.authorMungan, Mesut
dc.contributor.authorTutar, Yusuf
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:28Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:28Z
dc.date.issued2013
dc.identifier.issn0929-8665
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8501
dc.descriptionWOS: 000326985700002en_US
dc.descriptionPubMed ID: 24261974en_US
dc.description.abstractToxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of T. gondii can cause acute infection, and it is called toxoplasmosis. The development of latent bradyzoites from rapidly growing tachyzoites has been linked to cellular and environmental stresses which are associated with heat shock proteins (Hsps). Hsps play a protective role against stressors. Hsp40 is an important member of Hsp family and T. gondii has 36 predicted Hsp40 family members. Therefore, we studied the cloning and biochemical characterization of the T. gondii RH strain Hsp40 protein-Gok1. Hsp40 prevents protein aggregation and induce refolding. Consequently, Hsp40s may play essential roles in the mechanisms of bradyzoite development and survival in the host organism. Hsp40-Gok1 functional and structural properties may facilitate drug design and protein targeting against toxoplasmosis.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey, TUBITAK [110T928]; TUBA-GEBIP [2008-29]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support received from the Scientific and Technological Research Council of Turkey, TUBITAK (Grant number 110T928) and partial support from TUBA-GEBIP for YT (2008-29).en_US
dc.language.isoengen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeat Shock protein 40en_US
dc.subjectToxoplasma gondiien_US
dc.subjectprotein foldingen_US
dc.subjectprotein aggregationen_US
dc.titleHeat Shock Protein 40-Gok1 Isolation from Toxoplasma gondii RH Strainen_US
dc.typearticleen_US
dc.relation.journalPROTEIN AND PEPTIDE LETTERSen_US
dc.contributor.department[Coskun, Kubra A. -- Ozgur, Aykut] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, Tokat, Turkey -- [Otag, Begum] Cumhuriyet Univ, Grad Sch Nat & Appl Sci, Dept Bioengn, Sivas, Turkey -- [Mungan, Mesut] Publ Hlth Inst Turkey, Dept Communicable Dis, Ankara, Turkey -- [Tutar, Yusuf] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkeyen_US
dc.identifier.volume20en_US
dc.identifier.issue12en_US
dc.identifier.endpage1301en_US
dc.identifier.startpage1294en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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