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Porous and spherical hydroxyapatite microcomposites for immunoglobulin G adsorption

Date

2013

Author

Akkaya, Birnur

Metadata

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Abstract

A novel porous and spherical hydroxyapatite (HA) microcomposite with an average diameter of 50-100 m was produced by suspension polymerization for the adsorption of human immunoglobulin G (IgG). The specific surface area of the pure HA and HA microcomposite were found to be 80.25 and 182.53 m(2)/g, respectively. Characterizations were performed with X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy analysis. The swelling ratio of the spherical HA microcomposites was 170%. The maximum adsorption of IgG from aqueous solution was observed at pH 7.0 (5 mM phosphate buffer) and at 45 degrees C in a batch system in which parallel separate experiments were performed independently. An IgG adsorption capacity value of up to 140 mg/g was obtained for the HA microcomposite. The IgG molecules could be repeatedly adsorbed and desorbed through the use of spherical microcomposites without a noticeable loss in the IgG adsorption capacity. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2764-2771, 2013

Source

JOURNAL OF APPLIED POLYMER SCIENCE

Volume

130

Issue

4

URI

https://dx.doi.org/10.1002/app.39341
https://hdl.handle.net/20.500.12418/8513

Collections

  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6175]



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