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dc.contributor.authorUnal, Mumin
dc.contributor.authorGursoy, Sinan
dc.contributor.authorAltun, Ahmet
dc.contributor.authorDuger, Cevdet
dc.contributor.authorKol, Iclal Ozdemir
dc.contributor.authorKaygusuz, Kenan
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorMimaroglu, Caner
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:49Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:49Z
dc.date.issued2013
dc.identifier.issn1226-4512
dc.identifier.issn2093-3827
dc.identifier.urihttps://dx.doi.org/10.4196/kjpp.2013.17.5.417
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8559
dc.descriptionWOS: 000331593200006en_US
dc.descriptionPubMed ID: 24227942en_US
dc.description.abstractThe aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats. Seventy albino Wistar rats were separated into 7 groups. Data for the control and sham groups were recorded. The ineffective dose of dexmedetomidine was investigated and found to be 3 mu g/kg. Each group was administered the following medications: 3 mg/kg morphine (intraperitoneal) to Group 3, 5 mu g/kg fentanyl (intraperitoneal) to Group 4, dexmedetomidine 3 mu g/kg (subcutaneously) to Group 5, dexmedetomidine 3 mu g/kg (subcutaneous)+3 mg/kg morphine (intraperitoneal) to Group 6 and finally 3 mu g/kg dexmedetomidine (subcutaneous)+5 mu g/kg fentanyl (intraperitoneal) to Group 7. Just before the application and 15, 30, 60, 90 and 120 min after the administration of medication, two measurements of tail flick (TF) and hot plate (HP) tests were performed. The averages of the measurements were recorded. TF and HP latencies were the main outcomes. The analgesic effect of the combinations with dexmedetomidine+morphine (Group 6) and dexmedetomidine+fentanyl (Group 7), compared to the analgesic effect of morphine alone and fentanyl alone was significantly higher at 15, 30, 60 and 90 minutes after administration. In this study, dexmedetomidine in ineffective doses, when combined with morphine and fentanyl, potentiates the effects of both morphine and fentanyl.en_US
dc.language.isoengen_US
dc.publisherKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGYen_US
dc.relation.isversionof10.4196/kjpp.2013.17.5.417en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute painen_US
dc.subjectDexmedetomidineen_US
dc.subjectFentanylen_US
dc.subjectMorphineen_US
dc.subjectPotentiationen_US
dc.titleIneffective Doses of Dexmedetomidine Potentiates the Antinociception Induced by Morphine and Fentanyl in Acute Pain Modelen_US
dc.typearticleen_US
dc.relation.journalKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGYen_US
dc.contributor.department[Unal, Mumin -- Gursoy, Sinan -- Duger, Cevdet -- Kol, Iclal Ozdemir -- Kaygusuz, Kenan -- Mimaroglu, Caner] Cumhuriyet Univ, Sch Med, Dept Anesthesiol, TR-58140 Sivas, Turkey -- [Altun, Ahmet -- Bagcivan, Ihsan] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDAltun, Ahmet -- 0000-0003-2056-8683en_US
dc.identifier.volume17en_US
dc.identifier.issue5en_US
dc.identifier.endpage422en_US
dc.identifier.startpage417en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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