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dc.contributor.authorKibar, Ayse Esin
dc.contributor.authorPac, Feyza Aysenur
dc.contributor.authorBalli, Sevket
dc.contributor.authorOflaz, Mehmet Burhan
dc.contributor.authorEce, Ibrahim
dc.contributor.authorBas, Veysel Nejat
dc.contributor.authorAycan, Zehra
dc.descriptionWOS: 000321919400026en_US
dc.descriptionPubMed ID: 23503947en_US
dc.description.abstractA direct effect of obesity on myocardial function has not been not well established. Our aim was to investigate the effect of body mass index (BMI) and homeostatic model assessment of insulin resistance (HOMA-IR) on left-ventricular (LV) myocardial function in normotensive overweight and obese children by tissue Doppler imaging (TDI). We calculated the mitral annular displacement index (DI) and myocardial performance index (MPI) using TDI indices of systolic and diastolic LV function. In this hospital-based, prospective cross-sectional study, we studied 60 obese (mean age 13.2 +/- A 2.0 years) and 50 normal children. Subjects were divided into three groups: group 1 (BMI < 25, n = 50, control), group 2 (BMI 25-29.9 kg/m(2), n = 30, overweight), and group 3 (BMI a parts per thousand yen 30 kg/m(2), n = 30, morbidly obese). Standard echocardiography showed increased LV diameters and LV mass/index and preserved ejection fraction in obese children. By TDI, LV systolic and diastolic function showed that peak late myocardial velocity (Em = 15.4 +/- A 2 cm/s), peak early myocardial velocity (Am = 8.7 +/- A 1.3 cm/s), Em/Am ratio (1.8 +/- A 0.3), isovolumetric relaxation time (IVRT = 59.2 +/- A 8.2 ms), MPI (0.39 +/- A 0.03), and DI (25.5 +/- A 3.2 %) of the lateral mitral annulus in the obese subgroups were significantly different from those of control subjects (18.2 +/- A 1.2 cm/sn, 6.9 +/- A 0.6 cm/sn, 2.6 +/- A 0.2, 51.2 +/- A 9.6 ms, 0.34 +/- A 0.03, and 33.13 +/- A 5.0 %, respectively; p < 0.001). These structural and functional abnormalities were significantly related to BMI. There were positive correlations between HOMA-IR, septal MPI, and LV mass. DI and MPI data indicated impaired subclinical LV function in all grades of isolated obesity at a preclinical stage. Insulin resistance and BMI correlated significantly with indices of LV function.en_US
dc.subjectObesity in childhooden_US
dc.subjectInsulin resistanceen_US
dc.subjectTissue Doppler imagingen_US
dc.subjectMyocardial performance indexen_US
dc.subjectDisplacement indexen_US
dc.subjectLeft-ventricular functionen_US
dc.titleEarly Subclinical Left-Ventricular Dysfunction in Obese Nonhypertensive Children: A Tissue Doppler Imaging Studyen_US
dc.relation.journalPEDIATRIC CARDIOLOGYen_US
dc.contributor.department[Kibar, Ayse Esin] Mersin Womens & Childrens Hosp, Dept Pediat Cardiol, Guneykent, Mersin, Turkey -- [Pac, Feyza Aysenur] Turkiye Yuksek Ihtisas Educ & Res Hosp, Dept Pediat Cardiol, Ankara, Turkey -- [Balli, Sevket] Balikkesir Hosp, Dept Pediat Cardiol, Balikkesir, Turkey -- [Oflaz, Mehmet Burhan] Cumhuriyet Univ, Sch Med, Dept Pediat Cardiol, Sivas, Turkey -- [Ece, Ibrahim] Yuzuncu Yil Univ, Dept Pediat Cardiol, Tip Fak, Van, Turkey -- [Bas, Veysel Nejat -- Aycan, Zehra] Childrens Hlth & Dis Training & Res Hosp, Dept Pediat Endocrinol, Dr Sami Ulus Obstet & Gynecol, Ankara, Turkeyen_US
dc.contributor.authorIDOflaz, Mehmet Burhan -- 0000-0003-1515-4654en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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