dc.contributor.author | Koca, Irfan | |
dc.contributor.author | Ozgur, Aykut | |
dc.contributor.author | Coskun, Kubra Acikalin | |
dc.contributor.author | Tutar, Yusuf | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:59:26Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:59:26Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.issn | 1464-3391 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.bmc.2013.04.021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8653 | |
dc.description | WOS: 000320347100024 | en_US |
dc.description | PubMed ID: 23664495 | en_US |
dc.description.abstract | In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in good yield through one pot reaction of 4-benzoyl-1, 5-diphenyl-1H-pyrazole-3-carbonyl chloride with ammonium thiocyanate and various amines. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR and elemental analysis. Anticancer activities of synthesized compounds were evaluated on human colon, liver and leukemia cancer cell lines. Cell culture studies have demonstrated significant toxicity of the compounds on the cell lines, and the levels of toxicity have altered in the presence of various side groups. These results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment. Furthermore, these compounds have a great potential and significance for further investigations. (C)2013 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | Turkish National Academy of Sciences [TUBA GEBIP 2008-29] | en_US |
dc.description.sponsorship | We deeply appreciate expert Mehmet Gilmus for helping on the analysis of IR spectra. This work was funded through a seed grant from the Turkish National Academy of Sciences (TUBA GEBIP 2008-29 for Y.T.). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.isversionof | 10.1016/j.bmc.2013.04.021 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pyrazole | en_US |
dc.subject | Acyl thiourea | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | Liver | en_US |
dc.subject | Colon | en_US |
dc.subject | Leukemia cell lines | en_US |
dc.title | Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety | en_US |
dc.type | article | en_US |
dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY | en_US |
dc.contributor.department | [Koca, Irfan] Bozok Univ, Fac Arts & Sci, Dept Chem, Yozgat, Turkey -- [Ozgur, Aykut -- Coskun, Kubra Acikalin] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, Tokat, Turkey -- [Tutar, Yusuf] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 13 | en_US |
dc.identifier.endpage | 3865 | en_US |
dc.identifier.startpage | 3859 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |