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dc.contributor.authorAltuntas, Emine Elif
dc.contributor.authorKaya, Ali
dc.contributor.authorUysal, Ismail Onder
dc.contributor.authorCevit, Omer
dc.contributor.authorIcagasioglu, Dilara
dc.contributor.authorMuderris, Suphi
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:59:48Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:59:48Z
dc.date.issued2013
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0b013e318286084a
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8706
dc.descriptionWOS: 000330078200019en_US
dc.descriptionPubMed ID: 23714976en_US
dc.description.abstractObjectives: Crimean-Congo hemorrhagic fever (CCHF), like other viral infections, may prolong mucociliary clearance time and increase nasal resistance in children. The aim of the present prospective case-control study was to study, using saccharin and anterior rhinomanometry tests, whether CCHF infections caused any change in nasal physiology. Methods: Overall, 40 subjects, 20 of whom had CCHF (group 1) and 20 of whom were healthy controls (group 2), were enrolled in this study. The definitive diagnosis of CCHF infection was made based on typical clinical and epidemiological findings and detection of CCHF virus-specific IgM by ELISA or of genomic segments of the CCHF virus by reverse transcription-polymerase chain reaction. Anterior rhinomanometry was performed in all participants according to current recommendations of the Committee Report on Standardization of Rhinomanometry. A saccharin test was used to evaluate mucociliary clearance, and nasal mucociliary clearance time was assessed with the saccharin test as described previously. Results: In our patients, the mean time from the application of saccharin crystals to the first feeling of a sweet taste was 6.77 +/- 3.25 minutes (range 2-16 min). In terms of the mean time from the application of saccharin crystals to the first feeling of a sweet taste, there was no difference between two groups. The mean total air flow was 637.60 +/- 76.18 mL/s (range 490-760 mL/s). The mean total nasal airway resistance was 0.24 +/- 0.03 Pa/mL s (range 0.20-0.31 Pa/mL s). In terms of the degree of nasal air flow and nasal airway resistance and the total air flow and total nasal airway resistance of each nostril, there was no difference between the 2 groups. Conclusions: The results obtained in anterior rhinomanometry and saccharin test showed that there was no statistically significant difference between CCHF (+) patients and controls. These results suggest us that CCHF virus infection does not affect nasal physiology. However, this is the first study performed on this issue and further studies on larger series need to be performed.en_US
dc.language.isoengen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.isversionof10.1097/SCS.0b013e318286084aen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectanterior rhinomanometryen_US
dc.subjectsaccharin testen_US
dc.subjectnasal mucociliary clearance timeen_US
dc.subjectnasal physiologyen_US
dc.titleAnterior Rhinomanometry and Determination of Nasal Mucociliary Clearance Time With the Saccharin Test in Children With Crimean-Congo Hemorrhagic Feveren_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CRANIOFACIAL SURGERYen_US
dc.contributor.department[Altuntas, Emine Elif -- Uysal, Ismail Onder -- Muderris, Suphi] Cumhuriyet Univ, Fac Med, Dept Otorhinolaryngol, TR-58140 Sivas, Turkey -- [Kaya, Ali -- Cevit, Omer -- Icagasioglu, Dilara] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume24en_US
dc.identifier.issue3en_US
dc.identifier.endpageE242en_US
dc.identifier.startpageE239en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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