dc.contributor.author | Koparir, Metin | |
dc.contributor.author | Orek, Cahit | |
dc.contributor.author | Parlak, Akif Evren | |
dc.contributor.author | Soylemez, Abdurrazak | |
dc.contributor.author | Koparir, Pelin | |
dc.contributor.author | Karatepe, Mustafa | |
dc.contributor.author | Dastan, Sevgi Durna | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:59:50Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:59:50Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.issn | 1768-3254 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.ejmech.2013.02.025 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8710 | |
dc.description | WOS: 000322855400034 | en_US |
dc.description | PubMed ID: 23517726 | en_US |
dc.description.abstract | A novel series of compounds were synthesized by cyclic condensation reaction of substituted isothiocyanate (2a-c) with 2-thiophenecarboxylic acid hydrazide (1) in the presence of ethyl alcohol, to obtain intermediate thiosemicarbazides (3a-c), which were further treated with sodium hydroxide in the presence of ethanol to obtain triazole derivatives (4a-c). The latter were refluxed with substituted secondary amines and formaldehyde for 6-10 h to afford Mannich bases (5a-k). The synthesized compounds were characterized on the basis of their spectral (IR, C-13 and H-1 NMR) data and evaluated for biological activities. Some of the compounds were found to exhibit significant antimicrobial and antioxidant activity. (C) 2013 Elsevier Masson SAS. All rights reserved. | en_US |
dc.description.sponsorship | FUBAP, Elazig, Turkey [FF.11.38] | en_US |
dc.description.sponsorship | This study was supported by FUBAP (grant number FF.11.38), Elazig, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | en_US |
dc.relation.isversionof | 10.1016/j.ejmech.2013.02.025 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 4-Substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones | en_US |
dc.subject | Mannich bases | en_US |
dc.subject | Biological activity | en_US |
dc.title | Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | en_US |
dc.contributor.department | [Koparir, Metin -- Orek, Cahit -- Soylemez, Abdurrazak] Firat Univ, Fac Sci, Dept Chem, TR-23169 Elazig, Turkey -- [Parlak, Akif Evren -- Karatepe, Mustafa] Firat Univ, Fac Sci, Dept Biochem, TR-23100 Elazig, Turkey -- [Koparir, Pelin] Inst Forens Med, Dept Chem, TR-44000 Malatya, Turkey -- [Dastan, Sevgi Durna] Cumhuriyet Univ, Dept Biol, Fac Sci, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Parlak, Akif Evren -- 0000-0002-2579-9985; orek, cahit -- 0000-0002-3854-1537 | en_US |
dc.identifier.volume | 63 | en_US |
dc.identifier.endpage | 346 | en_US |
dc.identifier.startpage | 340 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |