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dc.contributor.authorOzdemir, Hakan
dc.contributor.authorEzirganli, Seref
dc.contributor.authorKara, M. Isa
dc.contributor.authorMihmanli, Ahmet
dc.contributor.authorBaris, Emre
dc.descriptionWOS: 000318322000013en_US
dc.descriptionPubMed ID: 23141995en_US
dc.description.abstractObjective: Platelet-rich fibrin (PRF) is a platelet and leukocyte rich and platelet preparation that concentrates various growth factors and therefore has the potential to be used as regenerative treatment. The aim of study was to assess the effects of platelet rich fibrin (PRF) on bone augmentation when used in conjunction with titanium barrier a rabbit calvaria model. Study design: Twenty-four adult male New Zealand rabbits were used in this study. Two titanium barriers were fixed on each rabbit's calvarium. The rabbits were divided into four groups (group one is control and the other three groups are experimental) and each group contains 6 animals. PRF, anorganic bovine bone (ABB), and biphasic calcium phosphate (BCP) were used with titanium barriers in the experimental groups. Any materials were not used in the control group. Half of the animals were sacrificed after 1 month, and the rest were sacrificed after 3 months. Histomorphometric evaluation was carried out in order to compare new bone formation among the groups. Results: Significantly more new bone area was noted in the PRF alone group than in the control group, no statistically significant differences were found among PRF, BCP and ABB groups after 1 month. PRF and ABB also had superior effects in new bone formation area control to the BCP group after 3 months. Conclusion: PRF may offer the ease of use, simple handling, and enhanced delivery of growth factors during the bone augmentation procedures. When used in conjunction with the titanium barriers, PEP use can increase the quality of the newly formed bone and enhance the rate of bone formation due to the concentration of growth factors. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipCumhuriyet University [DIS-080]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number DIS-080.en_US
dc.subjectGuided bone regenerationen_US
dc.subjectPlatelet rich fibrinen_US
dc.subjectAnorganic bovine boneen_US
dc.subjectBiphasic calcium phosphateen_US
dc.subjectTitanium barrieren_US
dc.titleEffects of platelet rich fibrin alone used with rigid titanium barrieren_US
dc.relation.journalARCHIVES OF ORAL BIOLOGYen_US
dc.contributor.department[Ozdemir, Hakan] Cumhuriyet Univ, Fac Dent, Dept Periodontol, Sivas, Turkey -- [Ezirganli, Seref -- Mihmanli, Ahmet] Bezmialem Vakif Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Istanbul, Turkey -- [Kara, M. Isa] Izmir Katip Celebi Univ, Fac Dent, Dept Oral & Maxillofacial Surg, TR-35180 Izmir, Turkey -- [Baris, Emre] Gazi Univ, Fac Dent, Dept Oral Pathol, Ankara, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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