Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure
dc.contributor.author | Nikolaou, Maria | |
dc.contributor.author | Parissis, John | |
dc.contributor.author | Yilmaz, M. Birhan | |
dc.contributor.author | Seronde, Marie-France | |
dc.contributor.author | Kivikko, Matti | |
dc.contributor.author | Laribi, Said | |
dc.contributor.author | Paugam-Burtz, Catherine | |
dc.contributor.author | Cai, Danlin | |
dc.contributor.author | Pohjanjousi, Pasi | |
dc.contributor.author | Laterre, Pierre-Francois | |
dc.contributor.author | Deye, Nicolas | |
dc.contributor.author | Poder, Pentti | |
dc.contributor.author | Cohen-Solal, Alain | |
dc.contributor.author | Mebazaa, Alexandre | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:00:24Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:00:24Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0195-668X | |
dc.identifier.issn | 1522-9645 | |
dc.identifier.uri | https://dx.doi.org/10.1093/eurheartj/ehs332 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8783 | |
dc.description | WOS: 000316128800011 | en_US |
dc.description | PubMed ID: 23091203 | en_US |
dc.description.abstract | The aim of this study was to assess the prevalence of abnormal liver function tests (LFTs) and the associated clinical profile and outcome(s) in acute decompensated heart failure (ADHF) patients. Alteration in LFTs is a recognized feature of ADHF, but prevalence and outcomes data from a broad contemporary cohort of ADHF are scarce and the mechanism(s) of ADHF-induced cholestasis is unknown. We conducted a post hoc analysis of SURVIVE, a large clinical trial including ADHF patients treated with levosimendan or dobutamine. All LFTs were available in 1134 patients at baseline. Abnormal LFTs were seen in 46 of ADHF patients: isolated abnormal alkaline phosphatase (AP) was noted in 11, isolated abnormal transaminases in 26, and a combination of abnormal AP and transaminases in 9. Abnormal AP was associated with marked signs of systemic congestion and elevated right-sided filling pressure. Abnormal AP had no relationship with 31-day mortality but was associated with worse 180-day mortality (23.5 vs. 34.9, P 0.001 vs. patients with normal AP). Abnormal transaminases were associated with clinical signs of hypoperfusion and with greater 31-day and 180-day mortality compared with normal transaminase profiles (17.6 vs. 8.4 and 31.6 vs. 22.4, respectively; both P 0.001). There was no additive value of abnormal AP plus abnormal transaminase on a long-term outcome. Abnormal LFTs were present in about a half of patients presenting with ADHF treated with inotropes. Abnormal AP and abnormal transaminases were associated with specific clinical, biological, and prognostic features, including a short-term overmortality with increased transaminases but not with biological signs of cholestasis, in ADHF patients. | en_US |
dc.description.sponsorship | Abbott; Orion Pharma | en_US |
dc.description.sponsorship | SURVIVE study was sponsored by Abbott and Orion Pharma. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | OXFORD UNIV PRESS | en_US |
dc.relation.isversionof | 10.1093/eurheartj/ehs332 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Heart failure | en_US |
dc.subject | Liver | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Inotropic agents | en_US |
dc.title | Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN HEART JOURNAL | en_US |
dc.contributor.department | [Nikolaou, Maria -- Yilmaz, M. Birhan -- Seronde, Marie-France -- Laribi, Said -- Deye, Nicolas -- Cohen-Solal, Alain -- Mebazaa, Alexandre] INSERM, UMRS 942, F-75010 Paris, France -- [Nikolaou, Maria -- Seronde, Marie-France -- Laribi, Said -- Paugam-Burtz, Catherine -- Cohen-Solal, Alain -- Mebazaa, Alexandre] Univ Paris Diderot, F-75205 Paris, France -- [Nikolaou, Maria -- Parissis, John] Univ Athens, Heart Failure Unit, Cardiol Dept 2, Attikon Univ Hosp, Athens, Greece -- [Seronde, Marie-France] Univ Hosp Jean Minjoz, Dept Cardiol, Besancon, France -- [Kivikko, Matti] Univ Helsinki, Cent Hosp, Dept Cardiol, Helsinki, Finland -- [Kivikko, Matti -- Pohjanjousi, Pasi] Orion Pharma, Kuopio, Finland -- [Laribi, Said] Hop Lariboisiere, AP HP, Dept Emergency Med, F-75475 Paris 10, France -- [Paugam-Burtz, Catherine] Hop Beaujon, AP HP, Dept Anesthesiol & Crit Med, F-92110 Clichy, France -- [Cai, Danlin] Abbott Labs, Abbott Pk, IL 60064 USA -- [Laterre, Pierre-Francois] Catholic Univ Louvain, Dept Crit Care Med, St Luc Univ Hosp, B-1200 Brussels, Belgium -- [Deye, Nicolas] Hop Lariboisiere, AP HP, Med ICU, F-75475 Paris 10, France -- [Poder, Pentti] North Estonia Med Ctr, Dept Cardiol 1, EE-12419 Tallinn, Estonia -- [Cohen-Solal, Alain] Hop Lariboisiere, AP HP, Dept Cardiol, F-75475 Paris 10, France -- [Mebazaa, Alexandre] Hop Lariboisiere, AP HP, Dept Anesthesiol & Crit Care Med, F-75475 Paris 10, France -- [Yilmaz, M. Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey | en_US |
dc.contributor.authorID | YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; Paugam-Burtz, Catherine -- 0000-0002-8168-7152; Mebazaa, Alexandre -- 0000-0001-8715-7753 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.endpage | 749 | en_US |
dc.identifier.startpage | 742 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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