dc.contributor.author | Ozdemir, Semra | |
dc.contributor.author | Uludag, Ahmet | |
dc.contributor.author | Silan, Fatma | |
dc.contributor.author | Atik, Sinem Yalcintepe | |
dc.contributor.author | Turgut, Bulent | |
dc.contributor.author | Ozdemir, Ozturk | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:00:44Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:00:44Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1513-7368 | |
dc.identifier.uri | https://dx.doi.org/10.7314/APJCP.2013.14.5.3213 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8824 | |
dc.description | WOS: 000331473400091 | en_US |
dc.description | PubMed ID: 23803106 | en_US |
dc.description.abstract | Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC). Materials and Methods: In the current case-control study, 60 differentiated thyroid cancers (DTC)- 45 papillary TC (PTC), 9 follicular TC(FTC) and 6 well-differentiated tumors of uncertain malignant potential (WDT-UMP) were examined. Results were compared to a healthy control group (n=58) from the same population. Genomic DNA was extracted from peripheral blood with EDTA and the target gene was genotyped by real-time PCR. Results: Carriers of the variant allele of MDR1 exon 26 polymorphism were at 2.8-fold higher risk of DTC than the control group (odds ratio [OR]: 0.3805, 95% confidence interval [Cl]: 0.1597-0.9065 (p>0.046). Conclusions: Presented results suggest that the MDR1 3435TT genotype might influence risk of development of DTC and that the CC genotype might be linked to a poor prognosis. Large-scale studies are now needed to validate this association. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ASIAN PACIFIC ORGANIZATION CANCER PREVENTION | en_US |
dc.relation.isversionof | 10.7314/APJCP.2013.14.5.3213 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Differentiated thyroid carcinoma | en_US |
dc.subject | MDR1 gene | en_US |
dc.subject | increased T allele frequency in codon C3435T | en_US |
dc.title | Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C > T Gene Polymorphism in Differentiated Thyroid Cancers | en_US |
dc.type | article | en_US |
dc.relation.journal | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | en_US |
dc.contributor.department | [Ozdemir, Semra -- Uludag, Ahmet -- Silan, Fatma -- Atik, Sinem Yalcintepe -- Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Fac Med, Dept Nucl Med, Canakkale, Turkey -- [Turgut, Bulent -- Ozdemir, Ozturk] Cumhuriyet Univ, Sivas, Turkey | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 3217 | en_US |
dc.identifier.startpage | 3213 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |