dc.contributor.author | Uslu, Ali Ugur | |
dc.contributor.author | Deveci, Koksal | |
dc.contributor.author | Korkmaz, Serdal | |
dc.contributor.author | Aydin, Bahattin | |
dc.contributor.author | Senel, Soner | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Sencan, Mehmet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:08Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:08Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | https://dx.doi.org/10.1155/2013/185317 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8879 | |
dc.description | WOS: 000321382100001 | en_US |
dc.description.abstract | Background. The purpose of the present study is to determine the association between neutrophil/lymphocyte ratio and both subclinical inflammation and amyloidosis in familial Mediterranean fever. Methods. Ninety-four patients with familial Mediterranean fever and 60 healthy volunteers were included in the study. Of the patients, 12 had familial Mediterranean fever related amyloidosis. The neutrophil/lymphocyte ratio of the patients was obtained from the hematology laboratory archive. Results. The neutrophil/lymphocyte ratio was significantly higher among persons with familial Mediterranean fever compared to healthy individuals (P < 0.0001). Also, neutrophil/lymphocyte ratio was significantly higher in patients with amyloidosis than in amyloidosis-free patients (P < 0.0001). Since NLR was evaluated in nonamyloid and amyloid stages of the same patient population (type 1 phenotype), we obtained significant statistical differences (1.95 +/- 0.30 versus 2.64 +/- 0.48, P < 0.05, resp.). With the cutoff value of neutrophil/lymphocyte ratio >2.21 and AUC = 0.734 (P = 0.009), it was a reliable marker in predicting the development of amyloidosis. Conclusion. The neutrophil/lymphocyte ratio, an emerging marker of inflammation, is higher in patients with familial Mediterranean fever in attack-free periods. The neutrophil/lymphocyte ratio may be a useful marker in predicting the development of amyloidosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | HINDAWI PUBLISHING CORPORATION | en_US |
dc.relation.isversionof | 10.1155/2013/185317 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever? | en_US |
dc.type | article | en_US |
dc.relation.journal | BIOMED RESEARCH INTERNATIONAL | en_US |
dc.contributor.department | [Uslu, Ali Ugur -- Aydin, Bahattin] Cumhuriyet Univ, Fac Med, Dept Internal Med, TR-58140 Sivas, Turkey -- [Deveci, Koksal -- Sancakdar, Enver] Cumhuriyet Univ, Dept Med Biochem, Fac Med, TR-58140 Sivas, Turkey -- [Korkmaz, Serdal -- Sencan, Mehmet] Cumhuriyet Univ, Fac Med, Dept Hematol, TR-58140 Sivas, Turkey -- [Senel, Soner] Erciyes Univ, Fac Med, Dept Rheumatol, Kayseri, Turkey | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |