Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo
dc.contributor.author | Tepe, Bektas | |
dc.contributor.author | Tuncer, Ersin | |
dc.contributor.author | Saraydin, Serpil Unver | |
dc.contributor.author | Ozer, Hatice | |
dc.contributor.author | Sen, Metin | |
dc.contributor.author | Karadayi, Kursat | |
dc.contributor.author | Inan, Deniz Sahin | |
dc.contributor.author | Karadayi, Sule | |
dc.contributor.author | Polat, Zubeyde | |
dc.contributor.author | Akpulat, Askin | |
dc.contributor.author | Duman, Mustafa | |
dc.contributor.author | Koksal, Binnur | |
dc.contributor.author | Turan, Mustafa | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:12Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:12Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0301-4851 | |
dc.identifier.issn | 1573-4978 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s11033-012-2098-6 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8916 | |
dc.description | WOS: 000312435500071 | en_US |
dc.description | PubMed ID: 23065225 | en_US |
dc.description.abstract | This work aims to investigate the antiproliferative properties of Allium sivasicum (AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38 % compared with the untreated rats. These results indicate that A. sivasicum has antitumoral potential against breast cancer. | en_US |
dc.description.sponsorship | Cumhuriyet University [T-383] | en_US |
dc.description.sponsorship | This work has been supported by the Scientific Research Project Fund of Cumhuriyet University under the project number T-383. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s11033-012-2098-6 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Allium sivasicum | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Antitumoral | en_US |
dc.subject | Extract | en_US |
dc.title | Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo | en_US |
dc.type | article | en_US |
dc.relation.journal | MOLECULAR BIOLOGY REPORTS | en_US |
dc.contributor.department | [Tepe, Bektas] Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci, TR-58140 Sivas, Turkey -- [Tuncer, Ersin -- Ozer, Hatice] Cumhuriyet Univ, Dept Pathol, Fac Med, TR-58140 Sivas, Turkey -- [Saraydin, Serpil Unver -- Inan, Deniz Sahin] Cumhuriyet Univ, Dept Histol & Embryol, Fac Med, TR-58140 Sivas, Turkey -- [Karadayi, Sule] Baskent Univ, Fac Med, Dept Thorax Surg, Adana, Turkey -- [Polat, Zubeyde] Cumhuriyet Univ, Dept Parasitol, Fac Med, TR-58140 Sivas, Turkey -- [Akpulat, Askin] Cumhuriyet Univ Sci, Dept Biol, TR-58140 Sivas, Turkey -- [Duman, Mustafa] Kosuyolu Educ & Res Hosp, Dept Gen Surg, Istanbul, Turkey -- [Koksal, Binnur] Cumhuriyet Univ, Dept Med Genet, Fac Med, TR-58140 Sivas, Turkey -- [Sen, Metin -- Karadayi, Kursat -- Turan, Mustafa] Cumhuriyet Univ, Dept Gen Surg, Fac Med, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | TEPE, Bektas -- 0000-0001-8982-5188 | en_US |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 604 | en_US |
dc.identifier.startpage | 597 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
This item appears in the following Collection(s)
-
Makale Koleksiyonu [5200]
Article Collection -
Makale Koleksiyonu [5745]
Article Collection -
Öksüz Yayınlar Koleksiyonu - WoS [6162]