dc.contributor.author | Bayrakli, Fatih | |
dc.contributor.author | Balaban, Hatice | |
dc.contributor.author | Ozum, Unal | |
dc.contributor.author | Duger, Cevdet | |
dc.contributor.author | Topaktas, Suat | |
dc.contributor.author | Kars, Hamit Zafer | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:15Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:15Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0940-6719 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s00586-012-2319-7 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8947 | |
dc.description | WOS: 000311780000025 | en_US |
dc.description | PubMed ID: 22526707 | en_US |
dc.description.abstract | To investigate the effect of an anti-TNF-alpha agent (etanercept) on recovery processes in a partial spinal cord injury (SCI) model using clinical and electrophysiological tests. Twenty-four New Zealand rabbits were divided into three groups: group 1 [SCI + 2 ml saline intramuscular (i.m.), n = 8], group 2 (SCI + 2.5 mg/kg etanercept, i.m., 2-4 h after SCI, n = 8) and group 3 (SCI + 2.5 mg/kg etanercept, i.m., 12-24 h after SCI, n = 8). Rabbits were evaluated before SCI, immediately after SCI, 1 week after, and 2 weeks after SCI, clinically by Tarlov scale and electrophysiologically by SEP. Tarlov scores of groups 2 and 3 were significantly better than group 1, 2 weeks after SCI. SEP recovery was significantly better in groups 2 and 3 than group 1, 2 weeks after SCI. These results show that blocking TNF-alpha mediated inflammation pathway by an anti-TNF-alpha agent enhances clinical and electrophysiological recovery processes in partial SCI model. | en_US |
dc.description.sponsorship | Cumhuriyet University [T-475] | en_US |
dc.description.sponsorship | This work is supported by the Scientific Research Project Fund of the Cumhuriyet University under project number T-475. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s00586-012-2319-7 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Spinal cord injury | en_US |
dc.subject | Inflammation | en_US |
dc.subject | TNF-alpha | en_US |
dc.subject | Etanercept | en_US |
dc.subject | Somatosensory evoked potentials | en_US |
dc.title | Etanercept treatment enhances clinical and neuroelectrophysiological recovery in partial spinal cord injury | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN SPINE JOURNAL | en_US |
dc.contributor.department | [Bayrakli, Fatih -- Ozum, Unal -- Kars, Hamit Zafer] Cumhuriyet Univ, Sch Med, Dept Neurosurg, TR-58140 Sivas, Turkey -- [Balaban, Hatice -- Topaktas, Suat] Cumhuriyet Univ, Sch Med, Dept Neurol, TR-58140 Sivas, Turkey -- [Duger, Cevdet] Cumhuriyet Univ, Sch Med, Dept Anesthesiol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.endpage | 2593 | en_US |
dc.identifier.startpage | 2588 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |