dc.contributor.author | Turkdogan, Kenan Ahmet | |
dc.contributor.author | Zorlu, Ali | |
dc.contributor.author | Guven, Fatma Mutlu Kukul | |
dc.contributor.author | Ekinozu, Ismail | |
dc.contributor.author | Eryigit, Umut | |
dc.contributor.author | Yilmaz, Mehmet Birhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:17Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:17Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0735-6757 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.ajem.2012.02.017 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8962 | |
dc.description | WOS: 000311997600021 | en_US |
dc.description | PubMed ID: 22633700 | en_US |
dc.description.abstract | Background: Matrix metalloproteinases (MMPs) have a central role in disease progression after ischemia-reperfusion injury. However, its prognostic significance in cardiac arrest (CA) patients having cardiopulmonary resuscitation (CPR) is unknown. The aim of this study was to investigate the relation between admission MMP-9 level and early mortality in CA patients. Methods: A total of 96 in-hospital or out-of-hospital CA patients and 40 age-and sex-matched healthy volunteers as the control group were evaluated prospectively. The patients were classified according to the CPR response into a successful group (n = 46) and a failed group (n = 50). Results: The MMP-9 levels were detected to be 56.9 +/- 4.3, 69.5 +/- 7.4, and 92.7 +/- 10.1 ng/mL in the control group, the successful CPR group (acute responders), and the failed CPR group, respectively (P < .001 for the 2 comparisons). The MMP-9 level on admission, presence of asystole, mean CA duration, out-of-hospital CPR, sodium and potassium levels, and arterial pH were found to have prognostic significance in univariate analysis. In addition, MMP-9 levels were correlated with age, troponin level, and oxygen saturation. In multivariate logistic regression analysis with forward stepwise method, only MMP-9 level on admission (odds ratio, 1.504; P < .001) and mean CA duration before CPR (odds ratio, 1.257; P = .019) remained associated with post-CPR early mortality after adjustment of other potential confounders. In addition, optimal cutoff value of MMP-9 to predict failed CPR was found as greater than 82 ng/mL, with 88% sensitivity and 97.8% specificity. Conclusions: High MMP-9 levels were associated with worse clinical and laboratory parameters, and it seems that MMP-9 helps risk stratification in CA patients. (C) 2012 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | en_US |
dc.relation.isversionof | 10.1016/j.ajem.2012.02.017 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Usefulness of admission matrix metalloproteinase 9 as a predictor of early mortality after cardiopulmonary resuscitation in cardiac arrest patients | en_US |
dc.type | article | en_US |
dc.relation.journal | AMERICAN JOURNAL OF EMERGENCY MEDICINE | en_US |
dc.contributor.department | [Zorlu, Ali] Bulanik State Hosp, Dept Cardiol, Mus, Turkey -- [Turkdogan, Kenan Ahmet -- Guven, Fatma Mutlu Kukul] Cumhuriyet Univ, Sch Med, Dept Emergency, Sivas, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Ekinozu, Ismail] Duzce Univ, Sch Med, Dept Cardiol, Duzce, Turkey -- [Eryigit, Umut] Karadeniz Tech Univ, Sch Med, Dept Emergency, Trabzon, Turkey | en_US |
dc.contributor.authorID | YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; kukul guven, fatma mutlu -- 0000-0003-3755-6021 | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.endpage | 1809 | en_US |
dc.identifier.startpage | 1804 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |