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dc.contributor.authorBolat, Fatih
dc.contributor.authorKilic, Suar Caki
dc.contributor.authorOflaz, Mehmet Burhan
dc.contributor.authorGulhan, Elif
dc.contributor.authorKaya, Ali
dc.contributor.authorGuven, Ahmet Sami
dc.contributor.authorAygunes, Utku
dc.contributor.authorIcagasioglu, Dilara
dc.contributor.authorGultekin, Asim
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:19Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:19Z
dc.date.issued2012
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.urihttps://dx.doi.org/10.3109/08880018.2012.725454
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8976
dc.descriptionWOS: 000310315000007en_US
dc.descriptionPubMed ID: 23013425en_US
dc.description.abstractNeonatal thrombocytopenia is one of the most common hematologic disorders in neonatal intensive care units (NICUs). The purpose of this study was to determine the prevalence of thrombocytopenia and whether thrombocytopenia has an effect on the occurrence of intraventricular hemorrhage (IVH) >= grade 2 and on mortality rate. This study was carried out retrospectively in neonates admitted to NICU of Cumhuriyet University in Sivas, Turkey, between 2009 and 2012. Among 2218 neonates evaluated, 208 (9.4%) developed thrombocytopenia. The prevalence of IVH >= grade 2 was more in infants with thrombocytopenia (7.2%) than in those without thrombocytopenia (4.4%), although this was not statistically significant (P=.08). In univariate analysis, IVH >= grade 2 was higher in cases with very severe thrombocytopenia (35.7%, n = 5) than in those with mild (2.1%, n = 2), moderate (4.7%, n = 3), and severe thrombocytopenia (15.2%, n = 5) (P=.04). Multivariate logistic regression analysis showed that birth weight <1500 g (OR 6.2, 95% CI 3.4-9.8; P=.0001), gram-negative sepsis (OR 2.5, 95% CI 1.8-4.2; P=.01), very severe thrombocytopenia (OR 1.3, 95% CI 1.1-2.1; P=.03), and platelet transfusion >= 2 (OR 7.3, 95% CI 4.1-12.1; P=.001) were significant risk factors for mortality. The results of our study suggest that outcomes of neonates with thrombocytopenia depend not only on platelet count but also on decreased gestational age or birth weight, prenatal factors, and sepsis.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.isversionof10.3109/08880018.2012.725454en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintraventricular hemorrhageen_US
dc.subjectmortalityen_US
dc.subjectneonatal intensive care uniten_US
dc.subjectprevalenceen_US
dc.subjectthrombocytopeniaen_US
dc.titleThe Prevalence and Outcomes of Thrombocytopenia in a Neonatal Intensive Care Unit: A Three-Year Reporten_US
dc.typearticleen_US
dc.relation.journalPEDIATRIC HEMATOLOGY AND ONCOLOGYen_US
dc.contributor.department[Bolat, Fatih] Cumhuriyet Univ, Div Neonatol, Dept Pediat, Fac Med, TR-58140 Sivas, Turkey -- [Kilic, Suar Caki] Cumhuriyet Univ, Fac Med, Dept Hematol, TR-58140 Sivas, Turkey -- [Oflaz, Mehmet Burhan] Cumhuriyet Univ, Fac Med, Dept Pediat Cardiol, TR-58140 Sivas, Turkey -- [Guven, Ahmet Sami -- Icagasioglu, Dilara] Cumhuriyet Univ, Fac Med, Dept Neurol, TR-58140 Sivas, Turkey -- [Bolat, Fatih -- Gultekin, Asim] Cumhuriyet Univ, Fac Med, Dept Neonatol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDOflaz, Mehmet Burhan -- 0000-0003-1515-4654en_US
dc.identifier.volume29en_US
dc.identifier.issue8en_US
dc.identifier.endpage720en_US
dc.identifier.startpage710en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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