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dc.contributor.authorOzer, Hatice
dc.contributor.authorYenicesu, Goncalmir
dc.contributor.authorArici, Sema
dc.contributor.authorCetin, Meral
dc.contributor.authorTuncer, Ersin
dc.contributor.authorCetin, Ali
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:23Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:23Z
dc.date.issued2012
dc.identifier.issn1746-1596
dc.identifier.urihttps://dx.doi.org/10.1186/1746-1596-7-124
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9010
dc.descriptionWOS: 000312601400001en_US
dc.descriptionPubMed ID: 22995373en_US
dc.description.abstractBackground: In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle. This study was designed to evaluate immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, and bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in typing of benign, borderline, and malignant serous and mucinous ovarian tumors. Methods: Total of 68 ovarian tumors, 25 benign [13 (19.1%) serous and 12 (17.6%) mucinous], 16 borderline [9 (13.2%) serous and 7(10.3%) mucinous], and 27 malignant ovarian tumors [24 (35.3%) serous and 3 (4.4%) mucinous tumors] were included in the study. Immunohistochemical expression of p53, p21, bax, bcl-2, telomerase, c-kit, and metallothionein were evaluated. Results: When all 68 cases were evaluated as benign, borderline, and malignant ovarian tumors without considering histopathological subtypes, the p53, p21, bax and metallothionein showed significantly higher staining scores in the borderline and malignant ones (p < 0.05). After evaluation of all 68 cases, the serous tumors showed significantly higher staining scores of p53, p21, c-kit, and metallothionein compared to the mucinous ones (p < 0.05). For differentiation of benign and borderline and malignant tumors combined, p53 was not used because all benign tumors has no staining, and p21, bax, and metallothionein was determined the significant predictors for borderline and malignant tumors combined (p < 0.05). For differentiation of borderline and malignant tumors, only p53 was determined the significant predictor for malignant tumors (p < 0.05). Conclusions: In conclusion, p53, p21, bax, c-kit, and metallothionein may be helpful for the typing of ovarian tumors as benign, borderline and malignant or serous and mucinous. p53, p21, bax, c-kit, and metallothionein may have different roles in the pathogenesis of ovarian tumor types. p53 and metallothionein may be helpful in the typing of borderline and malignant ovarian tumors. The immunohistochemical staining with bcl-2 and telomerase may not provide meaningful contribution for the typing of ovarian tumors.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University (Sivas, Turkey) [T-293]en_US
dc.description.sponsorshipThis work was supported by grant from the Scientific Research Project Fund of Cumhuriyet University (Sivas, Turkey) under the Project number of T-293.en_US
dc.language.isoengen_US
dc.publisherBIOMED CENTRAL LTDen_US
dc.relation.isversionof10.1186/1746-1596-7-124en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvarian tumorsen_US
dc.subjectImmunohistochemistryen_US
dc.subjectp53, p21, bax, bcl-2en_US
dc.subjectTelomeraseen_US
dc.subjectc-kiten_US
dc.subjectMetallothioneinen_US
dc.titleImmunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumorsen_US
dc.typearticleen_US
dc.relation.journalDIAGNOSTIC PATHOLOGYen_US
dc.contributor.department[Ozer, Hatice -- Tuncer, Ersin] Cumhuriyet Univ, Dept Pathol, Fac Med, TR-58140 Sivas, Turkey -- [Yenicesu, Goncalmir -- Cetin, Meral -- Cetin, Ali] Cumhuriyet Univ, Dept Obstet & Gynecol, Fac Med, TR-58140 Sivas, Turkey -- [Arici, Sema] BezmialemVakif Univ, Dept Pathol, Fac Med, Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.identifier.volume7en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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