dc.contributor.author | Kilic, Duygu | |
dc.contributor.author | Kesim, Servet | |
dc.contributor.author | Liman, Narin | |
dc.contributor.author | Sumer, Zeynep | |
dc.contributor.author | Ozturk, Ahmet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:30Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:30Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1310-2818 | |
dc.identifier.issn | 1314-3530 | |
dc.identifier.uri | https://dx.doi.org/10.5504/BBEQ.2012.0030 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9054 | |
dc.description | WOS: 000307803600016 | en_US |
dc.description.abstract | The choice of filling material is an important factor in the clinical success of root coverage. Therefore, the cytotoxicity of filling materials must be investigated to ensure a safe biological response. The aim of this study was to compare the response of L929 mouse fibroblasts to several glass ionomer cements (GICs), i.e. conventional GIC, resin-modified glass ionomer cement (RMGIC) and polyacid-modified resin composite (PMRC), using three different methods. 1) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay 2) agar diffusion test, 3) scanning electron microscopy The MTT test demonstrated that L929 fibroblast attachment to polyacid-modified resin composite filling material was excessive on day I, but decreased on day 3 (P < 0.05). When the cell proliferation percentages of all filling materials were compared with those of the control group (100%) on days 1 and 3, it was observed that statistically significant differences existed (P < 0.05). Although resin-modified glass ionomer cement was determined to be slightly cytotoxic according to the results of agar diffusion tests, differences between the groups were not significant (P > 0.05). In addition to our in vitro research results, chemical surface analysis techniques, measurement of the release of elements, physical surface characterization and analysis of microstructure and porosity can provide a better understanding of the biological response to filling materials. | en_US |
dc.description.sponsorship | Research Fund for PhD theses, Erciyes University, Turkey [B-591] | en_US |
dc.description.sponsorship | This study was supported by grant B-591 from the Research Fund for PhD theses, Erciyes University, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.relation.isversionof | 10.5504/BBEQ.2012.0030 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | fibroblast | en_US |
dc.subject | MTT | en_US |
dc.subject | cytotoxity | en_US |
dc.subject | glass ionomer cement | en_US |
dc.subject | cell morphology | en_US |
dc.title | IN VITRO COMPARISON OF THE EFFECTS OF DENTAL FILLING MATERIALS ON MOUSE FIBROBLASTS | en_US |
dc.type | article | en_US |
dc.relation.journal | BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | en_US |
dc.contributor.department | [Kesim, Servet] Erciyes Univ, Fac Dent, Kayseri, Turkey -- [Liman, Narin] Erciyes Univ, Fac Vet Med, Kayseri, Turkey -- [Sumer, Zeynep] Cumhuriyet Univ, Fac Med, Sivas, Turkey -- [Ozturk, Ahmet] Erciyes Univ, Fac Med, Kayseri, Turkey | en_US |
dc.contributor.authorID | Ozturk, Ahmet -- 0000-0002-7130-5624 | en_US |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 3162 | en_US |
dc.identifier.startpage | 3155 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |