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dc.contributor.authorSiverekli, Neslihan Berkdemir
dc.contributor.authorSahin, Ozlem
dc.contributor.authorSenel, Soner
dc.contributor.authorHayta, Emrullah
dc.contributor.authorKaptanoglu, Ece
dc.contributor.authorElden, Hasan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:31Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:31Z
dc.date.issued2012
dc.identifier.issn0172-8172
dc.identifier.urihttps://dx.doi.org/10.1007/s00296-011-1980-1
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9060
dc.descriptionWOS: 000306827500034en_US
dc.descriptionPubMed ID: 21739129en_US
dc.description.abstractThe aim of this study was to evaluate the bone mineral density (BMD) in familial Mediterranean fever (FMF) and to search the effects of genetic factors, family history of FMF and types of clinical attacks on BMD. Forty-four attack-free patients with FMF and 36 healthy voluntary subjects were included in the study. BMD measurements of lumbar spine and left proximal femur were performed by dual energy X-ray absorptiometry (DEXA). There was no statistically significant difference between patient and control groups regarding median values of lumbar BMD (P = 0.06), lumbar T (P = 0.08) and Z (P = 0.12) scores, femoral neck BMD (P = 0.13), femoral T (P = 0.22) and Z (P = 0.16) scores and total femur BMD (P = 0.14), T (P = 0.19) and Z (P = 0.27) scores. Patients with negative FMF family history had significantly lower femoral neck BMD (P = 0.018), femoral neck T (P = 0.009) and Z (P = 0.01) scores and total femur BMD (P = 0.033) than patients with positive FMF family history. There was no significant difference among the groups regarding mutation characteristic and types of attacks in lumbar BMD, T and Z scores, femoral neck BMD, T and Z scores and total femur BMD, T and Z scores (P > 0.05). We found that the bone loss of patients with FMF is not different from that of the controls. The increased bone loss in the patients with negative family history for FMF should be further investigated with larger patient groups taking into consideration of the risk factors related to family history for osteoporosis.en_US
dc.language.isoengen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.isversionof10.1007/s00296-011-1980-1en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectFamily historyen_US
dc.subjectOsteoporosisen_US
dc.subjectDual X-ray absorptiometryen_US
dc.titleBone mineral density in familial Mediterranean feveren_US
dc.typearticleen_US
dc.relation.journalRHEUMATOLOGY INTERNATIONALen_US
dc.contributor.department[Siverekli, Neslihan Berkdemir -- Sahin, Ozlem -- Senel, Soner -- Hayta, Emrullah -- Kaptanoglu, Ece -- Elden, Hasan] Cumhuriyet Univ, Fac Med, Dept Rheumatol, TR-58141 Sivas, Turkeyen_US
dc.identifier.volume32en_US
dc.identifier.issue8en_US
dc.identifier.endpage2457en_US
dc.identifier.startpage2453en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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