dc.contributor.author | Ozdemir, E. | |
dc.contributor.author | Bagcivan, I. | |
dc.contributor.author | Gursoy, S. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:40Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0090-2977 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s11062-012-9278-9 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9112 | |
dc.description | WOS: 000304912800005 | en_US |
dc.description.abstract | The efficacy of opioids in chronic pain treatment is limited because of the development of opioid tolerance. We investigated the role of N-methyl-D-aspartate (NMDA) receptor antagonists (NMDAR Ants) in morphine analgesia and tolerance in rats. To induce the morphine tolerance, experimental rats received morphine (50 mg/kg; subcutaneously) once daily for 3 days. After the last dose of morphine was injected on day 4 and morphine tolerance was evaluated, analgesic effects of ketamine, dizocilpine (MK-801, a non-competitive NMDAR Ant), LY235959 (a competitive NMDAR Ant), cis-2,3-piperidinedicarboxylic acid (PDA, an NMDAR agonist), and morphine were estimated with 30-min-long intervals (0, 30, 60, 90, and 120 min) by the tail-flick and hot-plate algesia tests (n = 6 in each studied group). As was found, ketamine, MK-801, and LY235959 significantly attenuated the development of morphine tolerance (P < 0.05). On the other hand, PDA somewhat increased the development of this tolerance, but the difference was not statistically significant (P > 0.05). Our data indicate that NMDAR Ants attenuate the development of morphine tolerance, significantly affecting the effects of morphine analgesia in rats. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s11062-012-9278-9 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | analgesia | en_US |
dc.subject | morphine | en_US |
dc.subject | NMDA antagonists | en_US |
dc.subject | ketamine | en_US |
dc.subject | MK-801 | en_US |
dc.title | Modulation of Morphine Analgesia and Tolerance in Rats by NMDA Receptor Antagonists | en_US |
dc.type | article | en_US |
dc.relation.journal | NEUROPHYSIOLOGY | en_US |
dc.contributor.department | [Ozdemir, E.] Cumhuriyet Univ, Sch Med, Dept Physiol, Sivas, Turkey -- [Bagcivan, I.] Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey -- [Gursoy, S.] Cumhuriyet Univ, Sch Med, Dept Anesthesiol & Reanimat, Sivas, Turkey | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 130 | en_US |
dc.identifier.startpage | 123 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |